RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene .[5] [6] [7]
This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[7]
Interactions [ edit ] CTDP1 has been shown to interact with WD repeat-containing protein 77 ,[8] GTF2F1 [6] POLR2A .[9]
References [ edit ]
^ a b c ENSG00000060069 GRCh38: Ensembl release 89: ENSG00000282752, ENSG00000060069 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033323 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae" . Proc Natl Acad Sci U S A . 94 (26): 14300–5. Bibcode :1997PNAS...9414300A . doi :10.1073/pnas.94.26.14300 PMC 24951 PMID 9405607 . ^ a b Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO" . J Biol Chem . 273 (42): 27593–601. doi :10.1074/jbc.273.42.27593 PMID 9765293 . ^ a b "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1" .^ Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP" . Nucleic Acids Res . 31 (3). England: 999–1005. doi :10.1093/nar/gkg197 . PMC 149217 PMID 12560496 . ^ Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A. 94 (11). UNITED STATES: 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 ISSN 0027-8424 . PMC 20825 PMID 9159119 .
External links [ edit ] Further reading [ edit ]
Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . Marshall NF, Dahmus GK, Dahmus ME (1998). "Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein" . J. Biol. Chem . 273 (48): 31726–30. doi :10.1074/jbc.273.48.31726 PMID 9822634 . Cho H, Kim TK, Mancebo H, et al. (1999). "A protein phosphatase functions to recycle RNA polymerase II" . Genes Dev . 13 (12): 1540–52. doi :10.1101/gad.13.12.1540 . PMC 316795 PMID 10385623 . Angelicheva D, Turnev I, Dye D, et al. (1999). "Congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome: a novel developmental disorder in Gypsies maps to 18qter" . Eur. J. Hum. Genet . 7 (5): 560–6. doi :10.1038/sj.ejhg.5200319 PMID 10439962 . Marshall NF, Dahmus ME (2000). "C-terminal domain phosphatase sensitivity of RNA polymerase II in early elongation complexes on the HIV-1 and adenovirus 2 major late templates" . J. Biol. Chem . 275 (42): 32430–7. doi :10.1074/jbc.M005898200 PMID 10938286 . Licciardo P, Napolitano G, Majello B, Lania L (2001). "Inhibition of Tat transactivation by the RNA polymerase II CTD-phosphatase FCP1" . AIDS . 15 (3): 301–7. doi :10.1097/00002030-200102160-00002 PMID 11273209 . S2CID 33054695 . Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat" . Virology . 296 (1): 6–16. doi :10.1006/viro.2002.1438 PMID 12036313 . Washington K, Ammosova T, Beullens M, et al. (2002). "Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II" . J. Biol. Chem . 277 (43): 40442–8. doi :10.1074/jbc.M205687200 PMID 12185079 . Mandal SS, Cho H, Kim S, et al. (2002). "FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation" . Mol. Cell. Biol . 22 (21): 7543–52. doi :10.1128/MCB.22.21.7543-7552.2002 . PMC 135672 PMID 12370301 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP" . Nucleic Acids Res . 31 (3): 999–1005. doi :10.1093/nar/gkg197 . PMC 149217 PMID 12560496 . Nguyen BD, Chen HT, Kobor MS, et al. (2003). "Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB". Biochemistry . 42 (6): 1460–9. doi :10.1021/bi0265473 . PMID 12578358 . Friedl EM, Lane WS, Erdjument-Bromage H, et al. (2003). "The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation" . Proc. Natl. Acad. Sci. U.S.A . 100 (5): 2328–33. Bibcode :2003PNAS..100.2328F . doi :10.1073/pnas.2628049100 PMC 151340 PMID 12591939 . Kamada K, Roeder RG, Burley SK (2003). "Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF" . Proc. Natl. Acad. Sci. U.S.A . 100 (5): 2296–9. Bibcode :2003PNAS..100.2296K . doi :10.1073/pnas.262798199 PMC 151334 PMID 12591941 . Nguyen BD, Abbott KL, Potempa K, et al. (2003). "NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1" . Proc. Natl. Acad. Sci. U.S.A . 100 (10): 5688–93. Bibcode :2003PNAS..100.5688N . doi :10.1073/pnas.1031524100 PMC 156262 PMID 12732728 . Varon R, Gooding R, Steglich C, et al. (2003). "Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome". Nat. Genet . 35 (2): 185–9. doi :10.1038/ng1243 . PMID 14517542 . S2CID 22461437 . Yu X, Chini CC, He M, et al. (2003). "The BRCT domain is a phospho-protein binding domain". Science . 302 (5645): 639–42. Bibcode :2003Sci...302..639Y . doi :10.1126/science.1088753 . PMID 14576433 . S2CID 29407635 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 .
