Big Butte may refer to:

• Big Butte Creek, tributary of the Rogue River in Oregon, United States
• Big Butte Springs, natural springs in Jackson County, Oregon, United States
• A fictitious town in Penn Zero: Part-Time Hero
• Big Butte (California), a mountain
• Big Butte (Nevada), a mountain
• Big Butte (Washington), a mountain

See also[edit]

• Big Butt Mountain (disambiguation), multiple summits in North Carolina, United States
• Big Southern Butte, lava domes in Idaho, United States