Protein-coding gene in the species Homo sapiens
A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene .[5] [6]
Function [ edit ] The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis . This protein has a cell cycle-dependent interaction with the RII subunit of PKA.[6]
Interactions [ edit ] AKAP8 has been demonstrated to interact with:
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000105127 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024045 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res . 238 (2): 305–16. doi :10.1006/excr.1997.3855 . PMID 9473338 . ^ a b "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8" .^ Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (Mar 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95" . Biochem. J . 378 (Pt 2): 673–9. doi :10.1042/BJ20031765 . PMC 1223988 PMID 14641107 . ^ Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase" . J. Biol. Chem . 276 (20): 17448–54. doi :10.1074/jbc.M101171200 PMID 11279182 . ^ Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication" . J. Biol. Chem . 278 (29): 26750–6. doi :10.1074/jbc.M300765200 PMID 12740381 . ^ Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex" . J. Biol. Chem . 277 (52): 50885–92. doi :10.1074/jbc.M206387200 PMID 12414807 . ^ Collas P, Le Guellec K, Taskén K (Dec 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis" . J. Cell Biol . 147 (6): 1167–80. doi :10.1083/jcb.147.6.1167 . PMC 2168084 PMID 10601332 .
Further reading [ edit ]
Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409–29, discussion 429–30. PMID 9238861 . Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol . 42 : 235–57. doi :10.1146/annurev.pharmtox.42.083101.135801 . PMID 11807172 . Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis" . J. Cell Biol . 147 (6): 1167–80. doi :10.1083/jcb.147.6.1167 . PMC 2168084 PMID 10601332 . Steen RL, Cubizolles F, Le Guellec K, Collas P (2000). "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract" . J. Cell Biol . 149 (3): 531–6. doi :10.1083/jcb.149.3.531 . PMC 2174845 PMID 10791967 . Akileswaran L, Taraska JW, Sayer JA, et al. (2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase" . J. Biol. Chem . 276 (20): 17448–54. doi :10.1074/jbc.M101171200 PMID 11279182 . Eide T, Carlson C, Taskén KA, et al. (2002). "Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting" . EMBO Rep . 3 (5): 426–32. doi :10.1093/embo-reports/kvf089 . PMC 1084102 PMID 11964380 . Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex" . J. Biol. Chem . 277 (52): 50885–92. doi :10.1074/jbc.M206387200 PMID 12414807 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Eide T, Taskén KA, Carlson C, et al. (2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication" . J. Biol. Chem . 278 (29): 26750–6. doi :10.1074/jbc.M300765200 PMID 12740381 . Arsenijevic T, Degraef C, Dumont JE, et al. (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95" . Biochem. J . 378 (Pt 2): 673–9. doi :10.1042/BJ20031765 . PMC 1223988 PMID 14641107 . Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Kamada S, Kikkawa U, Tsujimoto Y, Hunter T (2005). "A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association" . Mol. Cell. Biol . 25 (21): 9469–77. doi :10.1128/MCB.25.21.9469-9477.2005 . PMC 1265837 PMID 16227597 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
External links [ edit ]
