The Tlacique are a fictional bloodline of vampires, from White Wolf Game Studio's Vampire: The Masquerade and Vampire: The Dark Ages books and role-playing games.
They reside in South America and are believed to be descended from the Followers of Set. This clan/bloodline possesses Protean instead of the clan discipline of Serpentis and also possesses a unique type of Sorcery which is rather powerful. They have an enmity with both the Camarilla and Sabbat, reaching back to the time of Christopher Columbus, when the European Kindred came over to South America and all but wiped out their mortal civilization. In the modern days, more and more Tlacique come into action again forming an alliance with the Pisanob Necromancers.
See also: tlahuelpuchi