Pharmacology Project‑class

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I have started including group names and navigation templates in the lead sections of the ATC level 2 pages (see e. g. ATC code A01). Any objections or alternative suggestions?

Also, the ATC code pages should have a uniform layout. The third-level groups are sometimes headers (as in ATC code A01), sometimes not (as in ATC code A02). The first layout is clearer, in my opinion; but it produces rather long TOCs. The first layout also seems to be the more common, so it would be less work changing in this direction. --ἀνυπόδητος (talk) 09:22, 4 December 2008 (UTC)[reply]

Hello. We have had a article requested with the above title at WP:AFC. I have little idea whether it should be created or not and am looking for advice. There's not much to it yet; it seems to be a loosely rewritten version of http://compbio.epm.br/kunitz/. If anyone would care to take a look and venture an opinion, it can be found at Articles for creation/Submissions/KUNITZ STI protease inhibitors. Thanks, Martin 21:22, 18 December 2008 (UTC)[reply]

You may want to ask over at WP:MCB. The subject of this request concerns "natural" protease inhibitors, that is, a class of proteins, not the protease inhibitors used to treat HIV. Fvasconcellos (t·c) 12:08, 19 December 2008 (UTC)[reply]

Thanks. I have no idea what it's about, as you can probably tell ;) Martin 01:07, 20 December 2008 (UTC)[reply]

P-kun80 appears to be systematically changing the IUPAC names of large numbers of drugs, with no reference given for the change (eg saquinavir diff: [1]). The edit summaries state "corrected IUPAC name" or "corrected IUPAC name (according to stereochemistry of the given image)". Could someone with chemical knowledge please take a look and see whether these make sense? I'm worried that the IUPAC name ought to be identical to whatever's given on the package insert. Thanks for your help, Espresso Addict (talk) 08:57, 22 December 2008 (UTC)[reply]

My guess is that most of the IUPAC names on chemicial/pharmaceutical articles come from PubChem or from ChemDraw's "Autonom" feature. 79.121.106.220 (talk · contribs), presumably the same as P-kun80, said on my talk page that he is using ChemBioDraw v11. Some of the changes P-kun80 is making are certainly an improvement - such as adding stereochemical assigments. I appreciate the effort he is making to fix these. But different programs for automatically generating IUPAC names give different results, and I really don't know if one is better than any other. IUPAC names aren't absolute - they are based on "recommendations" (that can change over time). At the very least, we should make sure that the structure and IUPAC name can be derived from each other. P-kun80's changes are definitely consistent with that. -- Ed (Edgar181) 12:00, 22 December 2008 (UTC)[reply]

Exactly. The IUPAC names given on package inserts are quite often inaccurate. No chemical naming tool generates "perfect" (notice the scare quotes—there is no perfect) systematic names 100% of the time; a 2006 study found that ACD/Name is the most accurate and reliable software package, and I believe it is used by quite a few Wikipedians (I use the somewhat limited freeware version), but I've checked a few of these recent changes and they check out OK. My only concern is that these new names may conflict with our data validation efforts. Fvasconcellos (t·c) 12:04, 22 December 2008 (UTC)[reply]

As Edgar181 have said, ChemBioDraw v11; cross-checked with MarvinSketch's similar feature. But if I should not do this, then someone should tell me how to find those pages which completely lack IUPAC names (and at the same time, describe a substance.) By the way, yes, that IP is mine.P-kun80 (talk) 12:19, 22 December 2008 (UTC)[reply]

Greetings to all, Reading the Microdosing page, I would be really interested to hear if anyone has any experience of using this technique and what you thought of it. Any views would be greatly appreciated! —Preceding unsigned comment added by Lisastockdale (talk • contribs) 00:36, 29 December 2008 (UTC)[reply]

Proposing to do it here Need to get second/third opinion. Now we have hundreds of requests of non notable proposed drug names and chemicals or misspelled diseases. And each day dozens article removed from Wikipedia because of non notability. Look at articles for deletion. So what I thinking is to remove non notable chemicals from requested articles list to save time and efforts(and requests for AfD take ppl time to discuss/vote etc., not mentioning actual creation of the arrticle itself).

Please comment on talk page of requested list. Thank you. TestPilot^{talk to me!} 12:53, 30 December 2008 (UTC)[reply]

I have started a discussion thread at WT:PHARM:CAT. kilbad (talk) 20:42, 2 January 2009 (UTC)[reply]

I'm asking for a review of this article's GA status. I think it's very disorganized. Xasodfuih (talk) 09:58, 3 January 2009 (UTC)[reply]

I've submitted a soundbite from that article I finished today to DYK. But verifying it requires access to the journal Steroids, so someone from here might want to undertake the verification. As far as I can tell, Pharma articles are seldom featured at DYK... Xasodfuih (talk) 16:14, 4 January 2009 (UTC)[reply]

2-Benzylpiperidine may need some expert reviewing as a drunk user notified me that there is some "improper articulation." kilbad (talk) 03:43, 10 January 2009 (UTC)[reply]

I'm not familiar with the compound, but I see nothing obviously wrong in that article. Based on your talk page he seems to be complaining about the use of the word "potent" as unscientific or shameful?! Well PMID 39160 (cited in the article) shamelessly uses it. So, he was either overly anal when drunk or just trolling you. Yeah, you could reword it to use "affinity" or other jargon, but the wording seems fine for a general encyclopedia. Xasodfuih (talk) 00:17, 11 January 2009 (UTC)[reply]

Also, looking at the history of that article, User:Meodipt wrote it. He wrote articles about other experimental compounds here. I had read some of the articles he wrote about various SARMs before seeing this notice, and found Meodipt's articles accurate with respect to the sources. So I trust the data is correct in this article as well, even though it's not in the abstracts of the reference papers; I didn't check the full text here because I have little interest in this. I think we're being trolled. Xasodfuih (talk) 00:32, 11 January 2009 (UTC)[reply]

Thanks for looking at that article. Also, what do you mean by "trolled"? kilbad (talk) 00:48, 11 January 2009 (UTC)[reply]

That from the tone and content of the complaint it appears it was done "for the lulz" (if I'm allowed to use an expression I've recently seen on WP:ANI). Xasodfuih (talk) 13:16, 11 January 2009 (UTC)[reply]

Actually, the user complained about the formulations "20 times less" and "175 times lower". This would be really bad style in German, but I am not sure about English. Shouldn't it be "a twentieth" or something like that? --ἀνυπόδητος (talk) 12:25, 12 January 2009 (UTC)[reply]

"Twenty times less" has been perfectly good English for the past 300 years or so according to Webster [2] ("Times has now been used in such constructions for about 300 years, and there is no evidence to suggest that it has ever been misunderstood"). The only "shameful" part may be using digits. "One-twentieth as potent ..." would be an alternative, but it's not anymore correct. Xasodfuih (talk) 12:50, 12 January 2009 (UTC)[reply]

As I said earlier.. English is not my native language.. however me and many non-natives still use en.wiki.. as their primary wiki. I think it would be better to say something like "desoxy and amphetamine are 20 time more potent than.." ..

Even if it has traditionally been used the way it has.. why should someone consciously sustain such irrational tradition? I bet that mathematicians (and others who think logically) strongly dislike that tradition anyways.

-Matriiq —Preceding unsigned comment added by Matriiq (talk • contribs) 09:10, 13 January 2009 (UTC)[reply]

The article Alitretinoin has been tagged for copypaste concerns, which automatically lists it at the copyright problems board. Investigation verifies that the text is the same as that at the identified source, [3] (page 2). Under ordinary circumstances, I'd remove it, but I am unfamiliar with the copyright status of drug indication descriptions. It seems plausible to me that drug indications might not be copyrightable; for instance, if they are generated by US federal agency and hence public domain. I'm hoping that your project can shed some light. :) I'll be grateful for responses even of the "can't help you" variety, since if your project doesn't know, I'll have to look elsewhere for an answer or remove the text, lacking verification that it is free for use. Thanks for any help you can offer. --Moonriddengirl ^(talk) 13:46, 12 January 2009 (UTC)[reply]

Unfortunately, I am equally unfamiliar with the copyright status of FDA-approved drug labeling. I've reworded the possibly offending text anyway because Wikipedia articles should not mirror drug monographs. If and when you do find out more, please let us know—this issue has come up several times before. Fvasconcellos (t·c) 21:50, 14 January 2009 (UTC)[reply]

Thank you for your help with that. I have not been able to find anything to verify that it is usable, but if I should, I will certainly let your project know. :) --Moonriddengirl ^(talk) 13:08, 15 January 2009 (UTC)[reply]

I am a new user with a concern on the wikipedia paroxetine page. The fourth sentence in the opening paragraph is "The prescription of this drug is controversial because of side effects such as suicidal ideation (thoughts of suicide) and withdrawal syndrome which have resulted in legal proceedings against the manufacturer."

I think this sentence is too strongly worded and does not belong in the opening paragraph. I think this sentence is alarmist and may cause more harm then good. It does not referense both sides of the supposed controversy.

I lack the knowledge of wikipedia protocol, but can someone review this? Thanks. Mwalla (talk) 21:38, 15 January 2009 (UTC)mwalla[reply]

Pharmacology says: "If substances have medicinal properties, they are considered pharmaceuticals."
I recently looked at a couple of articles on herbal medicine (Herbalism, Chinese herbology) which are not listed as part of this WikiProject but which I think should be. Shall I add articles on herbal medicine to this project, or should I not? Thanks. -- 201.37.230.43 (talk) 23:35, 13 January 2009 (UTC)[reply]

Apologies if this a duplicate notification. Xasodfuih (talk) 02:40, 18 January 2009 (UTC)[reply]

User:Jmh649 has nominated Paracetamol for a featured article review here. Please join the discussion on whether this article meets the featured article criteria. Articles are typically reviewed for two weeks. If substantial concerns are not addressed during the review period, the article will be moved to the Featured Article Removal Candidates list for a further period, where editors may declare "Keep" or "Delist" in regards to the article's featured status. The instructions for the review process are here. SandyGeorgia (Talk) 23:21, 20 January 2009 (UTC)[reply]

How do people feel about having pages for vaccines that don't exist yet (for example, Epstein-Barr vaccine, Trypanosomiasis vaccine, and Schistosomiasis vaccine)? I think that the issues are similar but not identical to the issues with small molecule drugs, so I'd like to get a sense from the community before going too much farther down that road. --Arcadian (talk) 18:46, 19 January 2009 (UTC)[reply]

Since I have created a number of stubs about small molecules in clinical trials myself, I obviously don't object as long as WP:CRYSTAL is observed (which you do anyway, Arcadian; the last bit was just for the general audience ). --ἀνυπόδητος (talk) 19:57, 19 January 2009 (UTC)[reply]

Should be merged with main topic unless vaccine in very advanced stage of development. JFW | T@lk 00:36, 20 January 2009 (UTC)[reply]

I would go for a slightly different criterion: what can we say about a possible vaccine, and what are the problems? To put it another way, how would such articles get out of being stubs? HIV vaccine exists only as an article: the article isn't great, but you can see how it could be improved with work. Of the three stubs mentioned, I can see Trypanosomiasis vaccine being improved (as an article, and without breakthroughs), but not the others: a subjective choice, I agree, but that's one of the ways we've built up WP. Physchim62 (talk) 00:57, 20 January 2009 (UTC)[reply]

An anonymous IP added the trade name "Dorafem" to rabeprazole on Proton pump inhibitor#Examples of proton pump inhibitors with the remark "combination therapy". I somewhat rashly added that it is a combination with domperidone, but I can't find a reliable source for this. Could someone, please, check? Thanks --ἀνυπόδητος (talk) 10:01, 20 January 2009 (UTC)[reply]

We're the topic of this week's The Wikipedia Signpost regular series of reports on Wikiprojects - see Wikipedia:Wikipedia_Signpost/2009-01-17/WikiProject_report :-)

Should that be added to the end of the project's "Pharmacology trophy case" section ? Anyway, well done Fvasconcellos ! David Ruben ^Talk 22:47, 20 January 2009 (UTC)[reply]

See discussion here. Xasodfuih (talk) 22:59, 25 January 2009 (UTC)[reply]

As most of you are aware, over at WP:Chem have been working for some time on trying to validate content in our Chemboxes. We'd like to be able to assist with validation of content in drugboxes, too. Last year we set up a collaboration with CAS whereby they will provide us with many of the CAS numbers for our Chemboxes. They are also setting up a free access website which has one page per compound - this will become available soon, maybe even in a week or two. Our validation work quite naturally includes a lot of Drugboxes, and some members of WP:PHARM have graciously assisted in our efforts. We are now at the stage of actively validating the content. It is hoped to expand the scope in the future to include IUPAC names, SMILES, and eventually even some physical properties.

For the Chembox, we set up a system for showing that a CAS No. was validated against the CAS collection - it appears in a dark green, bold font. (Black = unchecked, Anber = checked but not fully validated, Red = validated version was edited, so highly suspect! We still need to set up an "explanation" page for users.) This is done through use of {{cascite}}, as here; at present, such edits have no effect on drugboxes. In addition, we have User:CheMoBot logging all edits to these data, as can be seen for drugboxes at Wikipedia:WikiProject_Pharmacology/Log, and we make a note of the validated versions of the articles here. It is hoped that we will be able to have CheMoBot able to revert edits that change these data fields from the correct version - after all, there should be no reason to change a CAS# supplied by CAS themselves. However, we're currently just logging the changes. I have a few questions:

• Does this project want to add in a colour coding system for drugboxes, or something equivalent, to indicate validated content?
• Currently you link from a CAS# to the National Library of Medicine entry for that CAS #. Would you consider linking to the appropriate CAS page from the CAS#, so that users can verify the CAS# for themselves? Over at WP:Chem, we are also considering linking to a link collection for that CAS#, but I suspect the most likely outcome for us would be something like this demo, but with a simple link (clicking on the CAS#) taking you to the CAS page for HCN.
• We're currently discussing some of these issues, and also how to validate structures and prevent their vandalism. If you'd like to join us on IRC, we're having a meeting on Tuesday on channel channel #wikichem at 1600h UTC.

I hope that you'll find this validation effort useful, and you can find a way to incorporate the information in a way that fits well with the project. Please feel free to respond here with your ideas, many of our group watch this page. Thanks! Walkerma (talk) 05:31, 26 January 2009 (UTC)[reply]

EMolecules may have fewer compounds that CAS, but for what's notable enough to be included in Wikipedia it seems more that sufficient. Also, it's free. It'd much prefer if the CAS numbers linked to a free site. Let's see what the new CAS (free) website will look like before making any decision. Xasodfuih (talk) 13:23, 26 January 2009 (UTC)[reply]

There is an effort afoot to link to ChemSpider and perform cross-validation of ChemSpider and Wikipedia structures. ChemSpider offers a lot of additional content above and beyond simply sourcing a supplier. it is of course free of charge --ChemSpiderMan (talk) 16:14, 26 January 2009 (UTC)[reply]