SAIC may refer to:
- SAIC Motor, a Chinese automaker formerly named Shanghai Automotive Industry Corporation
- School of the Art Institute of Chicago, one of America's largest accredited independent schools of art and design, located in the Loop in Chicago, Illinois
- Science Applications International Corporation, an American government contractor
- Science Applications International Corporation, the heritage name of Leidos
- Scottish Aquaculture Innovation Centre
- Single antenna interference cancellation, a promising technology to boost the capacity of GSM networks without any needed change in the network
- South African Indian Congress, an organization founded in 1924 in Natal (now KwaZulu-Natal), South Africa
- Special Agent in Charge, a detective or investigator for a state, county, municipal, federal or tribal government
- State Administration for Industry and Commerce, an abolished authority in the People's Republic of China responsible for advancing legislation concerning the administration of industry and commerce