The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis [5] and post COVID-19 condition.[6]
Schäfer BW, Heizmann CW (April 1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends in Biochemical Sciences. 21 (4): 134–140. doi:10.1016/S0968-0004(96)80167-8. PMID8701470.
Nacken W, Roth J, Sorg C, Kerkhoff C (April 2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microscopy Research and Technique. 60 (6): 569–580. doi:10.1002/jemt.10299. PMID12645005. S2CID10145841.
Roth J, Vogl T, Sorg C, Sunderkötter C (April 2003). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends in Immunology. 24 (4): 155–158. doi:10.1016/S1471-4906(03)00062-0. PMID12697438.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID1286667. S2CID41855774.
Schäfer T, Sachse GE, Gassen HG (January 1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells". Biological Chemistry Hoppe-Seyler. 372 (1): 1–4. doi:10.1515/bchm3.1991.372.1.1. PMID2039599.
Dorin JR, Emslie E, van Heyningen V (November 1990). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics. 8 (3): 420–426. doi:10.1016/0888-7543(90)90027-R. PMID2149559.
Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR, Van Heyningen V (October 1988). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues". Journal of Cell Science. 91 ( Pt 2) (2): 221–230. doi:10.1242/jcs.91.2.221. PMID3267695.
Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (February 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–643. doi:10.1016/0888-7543(95)80005-7. PMID7759097.
Umekawa T, Kurita T (September 1994). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone". Biochemistry and Molecular Biology International. 34 (2): 309–313. PMID7849642.
Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (February 1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". Journal of Dental Research. 72 (2): 517–523. doi:10.1177/00220345930720020801. PMID8423249. S2CID8311930.
Marti T, Erttmann KD, Gallin MY (April 1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications. 221 (2): 454–458. doi:10.1006/bbrc.1996.0616. PMID8619876.
PDB gallery
1mr8: MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN
1xk4: Crystal structure of human calprotectin(S100A8/S100A9)