Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene .[5] [6] [7] [8] [9]
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[9]
^ a b c GRCh38: Ensembl release 89: ENSG00000155827 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028309 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions" . Mol Cell . 20 (5): 759–70. doi :10.1016/j.molcel.2005.11.012 . PMID 16337599 .
^ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p" . J Biol Chem . 278 (37): 34739–42. doi :10.1074/jbc.C300269200 . PMID 12876294 .
^ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression" . Genes Dev . 22 (19): 2664–76. doi :10.1101/gad.1703008 . PMC 2559905 . PMID 18832071 .
^ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor" . Mol Biol Cell . 20 (3): 757–68. doi :10.1091/mbc.E08-09-0983 . PMC 2633391 . PMID 19037095 .
^ a b "Entrez Gene: RNF20 ring finger protein 20" .
Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas" . Proc. Natl. Acad. Sci. U.S.A . 97 (18): 10209–13. Bibcode :2000PNAS...9710209L . doi :10.1073/pnas.180316097 . PMC 27813 . PMID 10954754 .
Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)" . J. Immunol . 165 (6): 3469–83. doi :10.4049/jimmunol.165.6.3469 . PMID 10975868 .
Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing" . J. Immunol . 165 (11): 6322–33. doi :10.4049/jimmunol.165.11.6322 . PMID 11086069 .
Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease" . J. Immunol . 166 (2): 1334–43. doi :10.4049/jimmunol.166.2.1334 . PMID 11145718 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control" . Mol. Cell . 11 (1): 261–6. doi :10.1016/S1097-2765(02)00826-2 . PMID 12535538 .
Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter" . Mol. Cell . 11 (1): 267–74. doi :10.1016/S1097-2765(02)00802-X . PMID 12535539 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. Bibcode :2004Natur.429..369H . doi :10.1038/nature02465 . PMC 2734081 . PMID 15164053 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 .
Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation" . Mol. Cell . 20 (4): 601–11. doi :10.1016/j.molcel.2005.09.025 . PMID 16307923 .