Frank Smith may refer to:

• Frank Smith (psycholinguist), American psycholinguist, researcher of educational systems and the nature of learning
• Frank Edward Smith (1876–1970), British physicist

• Frank Smith (animator) (1911–1975), American animator
• Frank Smith (General Hospital), a fictional character on the American soap opera General Hospital
• Officer Frank Smith, fictional police detective, played by Ben Alexander, in the 1951 TV series Dragnet
• Frank Hill Smith (1842–1904), American artist and interior designer
• Frank Kingston Smith, Jr., American radio personality
• Frank Kingston Smith Sr. (1919–2003), American author and criminal attorney
• Frank Vining Smith (1879–1967), American marine painter
• Frank H. Smith, American media executive and producer

• Francis Marion Smith (1846–1931), borax mining magnate
• Frank L. Smith Bank, a 1905 bank whose building was designed by Frank Lloyd Wright
• Sir Frank Ewart Smith (1897–1995), deputy chairman Imperial Chemical Industries, and chief engineer of armament for Britain during WWIl
• Frank Smith (1880-1967), founder of The Smith's Snackfood Company in 1920

• Frank Smith (Canadian politician) (1822–1901), Canadian senator and businessman
• Frank Smith (Florida settler), Florida state representative and settler
• Frank Smith (D.C. Council) (born 1942), civil rights activist and politician in Washington, D.C.
• Frank Smith (Montana politician) (born 1942), Montana state senator
• Frank Smith (Connecticut politician), member of the Connecticut House of Representatives
• Frank Owens Smith (1859–1924), U.S. representative from Maryland
• Frank L. Smith (1867–1950), U.S. representative from Illinois
• Frank G. Smith (1872–1950), justice of the Arkansas Supreme Court
• Frank Ellis Smith (1918–1997), U.S. representative from Mississippi
• Frank Smith (British politician) (1854–1940), British Christian Socialist politician
• Frank Smith (New South Wales politician) (1852–1910), New South Wales politician
• Frank Smith (South Australian politician) (1888–1948), South Australian politician
• Frank L. Smith (New York politician) (1851–1926), American farmer and politician from New York
• Frank Smith (Kansas politician) (born 1952), member of the Kansas state legislature

• Brun Smith (Frank Brunton Smith, 1922–1997), New Zealand cricketer
• Frank Smith (cricketer, born 1893) (1893–1975), New Zealand cricketer
• Frank Smith (1900s pitcher) (1879–1952), Major League Baseball (MLB) pitcher
• Frank Smith (1950s pitcher) (1928–2005), MLB pitcher
• Frank Smith (Australian rules footballer) (1905–1968), Australian footballer for Melbourne
• Frank Smith (catcher) (1857–1928), MLB catcher
• Frank Smith (footballer, born 1889) (1889–1982), English footballer
• Frank Smith (footballer, born 1897) (1897–1988), English footballer
• Frank Smith (footballer, born 1936), English football goalkeeper
• Frank Smith (ice hockey) (1894–1964), Canadian ice hockey administrator
• Frank Smith (rugby union) (1886–1954), Australian rugby union player and Olympic gold medalist
• Frank Smith (sailor), British Olympic sailor
• Frank Smith (umpire) (1872–1943), English cricketer and Test umpire
• Frank M. Smith, American yacht racer
• Frank M. Smith Jr. (1927–1998), American sports broadcasting executive
• Frank Smith Sr., rugby league footballer of the 1930s, and 1940s
• Frank Smith Jr., rugby league footballer of the 1960s
• Frank Smith (Canadian football) (born 1931), played in the 1950s, coached UBC to five conference titles
• Frank Smith (American football) (born 1981), American football coach

• Frank Elmer Smith (1864–1943), American Medal of Honor recipient
• Frank E. Smith, president of the National Association of Letter Carriers

• Francis Smith (disambiguation)
• Frank Smyth (1891–1972), New Zealand rugby union player
• Frank Smythe (1900–1949), British mountaineer
• Franklin W. Smith (1826–1911), American abolitionist