Protein-coding gene in the species Homo sapiens
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene .[ 5]
Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins . It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.[ 5]
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Mononen I, Fisher KJ, Kaartinen V, Aronson NN (1993). "Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation" . FASEB J . 7 (13): 1247–56. doi :10.1096/fasebj.7.13.8405810 . PMID 8405810 . S2CID 21771613 .
Enomaa N, Heiskanen T, Halila R, et al. (1992). "Human aspartylglucosaminidase. A biochemical and immunocytochemical characterization of the enzyme in normal and aspartylglucosaminuria fibroblasts" . Biochem. J . 286 ( Pt 2) (Pt 2): 613–8. doi :10.1042/bj2860613 . PMC 1132942 . PMID 1530592 .
Ikonen E, Baumann M, Grön K, et al. (1991). "Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease" . EMBO J . 10 (1): 51–8. doi :10.1002/j.1460-2075.1991.tb07920.x . PMC 452610 . PMID 1703489 .
Morris C, Heisterkamp N, Groffen J, et al. (1992). "Chromosomal localization of the human glycoasparaginase gene to 4q32-q33". Hum. Genet . 88 (3): 295–7. doi :10.1007/BF00197262 . PMID 1733831 . S2CID 8805853 .
Ikonen E, Enomaa N, Ulmanen I, Peltonen L (1992). "In vitro mutagenesis helps to unravel the biological consequences of aspartylglucosaminuria mutation". Genomics . 11 (1): 206–11. doi :10.1016/0888-7543(91)90120-4 . PMID 1765378 .
Park H, Fisher KJ, Aronson NN (1991). "Genomic structure of human lysosomal glycosylasparaginase" . FEBS Lett . 288 (1–2): 168–72. doi :10.1016/0014-5793(91)81027-6 . PMID 1840528 . S2CID 26680929 .
Mononen T, Mononen I, Matilainen R, Airaksinen E (1991). "High prevalence of aspartylglycosaminuria among school-age children in eastern Finland". Hum. Genet . 87 (3): 266–8. doi :10.1007/BF00200902 . PMID 1864600 . S2CID 8240322 .
Fisher KJ, Aronson NN (1991). "Characterization of the mutation responsible for aspartylglucosaminuria in three Finnish patients. Amino acid substitution Cys163----Ser abolishes the activity of lysosomal glycosylasparaginase and its conversion into subunits" . J. Biol. Chem . 266 (18): 12105–13. doi :10.1016/S0021-9258(18)99071-X . PMID 1904874 .
Mononen I, Heisterkamp N, Kaartinen V, et al. (1991). "Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase" . Proc. Natl. Acad. Sci. U.S.A . 88 (7): 2941–5. Bibcode :1991PNAS...88.2941M . doi :10.1073/pnas.88.7.2941 . PMC 51356 . PMID 2011603 .
Halila R, Baumann M, Ikonen E, et al. (1991). "Human leucocyte aspartylglucosaminidase. Evidence for two different subunits in a more complex native structure" . Biochem. J . 276 ( Pt 1) (Pt 1): 251–6. doi :10.1042/bj2760251 . PMC 1151172 . PMID 2039475 .
Fisher KJ, Tollersrud OK, Aronson NN (1991). "Cloning and sequence analysis of a cDNA for human glycosylasparaginase. A single gene encodes the subunits of this lysosomal amidase" . FEBS Lett . 276 (1–2): 232. doi :10.1016/0014-5793(90)80551-S . PMID 2265705 . S2CID 221417722 .
Fisher KJ, Tollersrud OK, Aronson NN (1990). "Cloning and sequence analysis of a cDNA for human glycosylasparaginase. A single gene encodes the subunits of this lysosomal amidase" . FEBS Lett . 269 (2): 440–4. doi :10.1016/0014-5793(90)81211-6 . PMID 2401370 . S2CID 8210082 .
Tollersrud OK, Aronson NN (1989). "Purification and characterization of rat liver glycosylasparaginase" . Biochem. J . 260 (1): 101–8. doi :10.1042/bj2600101 . PMC 1138631 . PMID 2775174 .
Enomaa NE, Lukinmaa PL, Ikonen EM, et al. (1993). "Expression of aspartylglucosaminidase in human tissues from normal individuals and aspartylglucosaminuria patients" . J. Histochem. Cytochem . 41 (7): 981–9. doi :10.1177/41.7.7685790 . PMID 7685790 .
McCormack AL, Mononen I, Kaartinen V, Yates JR (1995). "Localization of the disulfide bond involved in post-translational processing of glycosylasparaginase and disrupted by a mutation in the Finnish-type aspartylglycosaminuria" . J. Biol. Chem . 270 (7): 3212–5. doi :10.1074/jbc.270.7.3212 . PMID 7852406 .
Tollersrud OK, Heiskanen T, Peltonen L (1994). "Human leucocyte glycosylasparaginase is an alpha/beta-heterodimer of 19 kDa alpha-subunit and 17 and 18 kDa beta-subunit" . Biochem. J . 300 ( Pt 2) (Pt 2): 541–4. doi :10.1042/bj3000541 . PMC 1138195 . PMID 8002961 .
Anabolism Catabolism Transport M6P tagging