Protein-coding gene in the species Homo sapiens
Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene . APOO is a member of the apolipoprotein family.[5]
The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide . The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL . Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[5]
Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL , LDL and VLDL .
^ a b c GRCh38: Ensembl release 89: ENSG00000184831 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079508 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart" . J. Biol. Chem . 281 (47): 36289–302. doi :10.1074/jbc.M510861200 . PMID 16956892 .