Protein-coding gene in the species Homo sapiens
V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene .[5] nuclear receptor family of intracellular transcription factors . It is named after its similarity to v-erbA (P03373 v-erbB in avian erythroblastosis virus .[6]
Function [ edit ] Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.[7] [8]
Interactions [ edit ] V-erbA-related gene has been shown to interact with:
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000160113 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002393 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (December 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other" . Nucleic Acids Research . 16 (23): 11057–74. doi :10.1093/nar/16.23.11057 . PMC 338996 PMID 2905047 . ^ Thormeyer, D; Baniahmad, A (October 1999). "The v-erbA oncogene (review)". International Journal of Molecular Medicine . 4 (4): 351–8. PMID 10493974 . ^ a b Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function" . Molecular and Cellular Biology . 20 (7): 2604–18. doi :10.1128/MCB.20.7.2604-2618.2000 . PMC 85476 PMID 10713182 . ^ Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription" . Circulation Research . 92 (9): 1033–40. doi :10.1161/01.RES.0000071355.82009.43 PMID 12690040 . ^ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2" . The Journal of Biological Chemistry . 274 (20): 14331–6. doi :10.1074/jbc.274.20.14331 PMC 2823254 PMID 10318855 .
Further reading [ edit ]
Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (July 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics . 43 (1): 107–9. doi :10.1006/geno.1997.4776 . PMID 9226381 . Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2" . The Journal of Biological Chemistry . 274 (20): 14331–6. doi :10.1074/jbc.274.20.14331 PMC 2823254 PMID 10318855 . Zhang Y, Dufau ML (January 2000). "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor" . The Journal of Biological Chemistry . 275 (4): 2763–70. doi :10.1074/jbc.275.4.2763 PMID 10644740 . Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function" . Molecular and Cellular Biology . 20 (7): 2604–18. doi :10.1128/MCB.20.7.2604-2618.2000 . PMC 85476 PMID 10713182 . Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription" . Circulation Research . 92 (9): 1033–40. doi :10.1161/01.RES.0000071355.82009.43 PMID 12690040 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 .
External links [ edit ]
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction