Cannabaceae

thcscience_admin
TCS-1205
Names
IUPAC name
2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • Key: VCKKJKQZHHPPDR-LLVKDONJSA-N
  • InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1
  • CC(C1=CC=CC=C1)NC(=O)C(=O)C2=CNC3=C2C=C(C=C3)[N+](=O)[O-]
Properties
C18H15N3O4
Molar mass 337.335 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

TCS 1205 is an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.

Pharmacology[edit]

TCS 1205 acts at the benzodiazepine binding site, it is selective for the a1 and a2 subunits of the GABAA receptor.[1] In vivo, it has anxiolytic effects but no sedative effects.[2][3]

Chemistry[edit]

Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a Nonbenzodiazepine.

References[edit]

  1. ^ https://documents.tocris.com/pdfs/tocris_coa/3941_1_coa.pdf?1706728634
  2. ^ "TCS 1205 | CAS 355022-97-8 | AbMole BioScience | TCS 1205 Price".
  3. ^ Taliani, Sabrina; Cosimelli, Barbara; Da Settimo, Federico; Marini, Anna Maria; La Motta, Concettina; Simorini, Francesca; Salerno, Silvia; Novellino, Ettore; Greco, Giovanni; Cosconati, Sandro; Marinelli, Luciana; Salvetti, Francesca; L’Abbate, Gianluca; Trasciatti, Silvia; Montali, Marina; Costa, Barbara; Martini, Claudia (25 June 2009). "Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor". Journal of Medicinal Chemistry. 52 (12): 3723–3734. doi:10.1021/jm9001154.


source: https://en.wikipedia.org/wiki/TCS-1205

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

Leave a Reply