| Subependymoma | |
|---|---|
 | |
| Micrograph of a subependymoma showing the characteristic clustering of nuclei. H&E stain. | |
| Specialty | Neoplasms, Neuro-oncology |
A subependymoma is a type of brain tumor; specifically, it is a rare form of ependymal tumor.[1] They are usually in middle aged people. Earlier, they were called subependymal astrocytomas.[2]
The prognosis for a subependymoma is better than for most ependymal tumors,[3] and it is considered a grade I tumor in the World Health Organization (WHO) classification.
They are classically found within the fourth ventricle, typically have a well demarcated interface to normal tissue and do not usually extend into the brain parenchyma, like ependymomas often do.[4]
Symptoms and signs[edit]
Patients are often asymptomatic, and are incidentally diagnosed. Larger tumours are often with increased intracranial pressure.[2]
Pathology[edit]
These tumours are small, no more than two centimeters across, coming from the ependyma. The best way to distinguish it from a subependymal giant cell astrocytoma is the size.[2]
Diagnosis[edit]
The diagnosis is based on tissue, e.g. a biopsy. Histologically subependymomas consistent of microcystic spaces and bland appearing cells without appreciable nuclear atypia or mitoses. The nuclei tend to form clusters.[citation needed]
On a CT, it often shows a less dense to equally dense mass. If it is big, it may have parts that are cystic or calcific.[2] In 50-60% of cases, the tumor is in the fourth ventricle, while the second most common (30-40% of cases) location is the side ventricles. It is rare for it to be in the third ventricle or the central canal of the spinal cord.[2]
Treatment[edit]
Asymptomatic cases may only need watchful waiting. If symptomatic, it can be surgically removed, and partial removal also carries an excellent prognosis.[2]
Prognosis[edit]
The outlook of a cure is extremely favorable.[2]
References[edit]
- ^ Orakcioglu B, Schramm P, Kohlhof P, Aschoff A, Unterberg A, Halatsch ME (January 2009). "Characteristics of thoracolumbar intramedullary subependymomas". Journal of Neurosurgery. Spine. 10 (1): 54–59. doi:10.3171/2008.10.SPI08311. PMID 19119934.
- ^ a b c d e f g Gaillard, Frank. "Subependymoma | Radiology Reference Article | Radiopaedia.org". radiopaedia.org. Retrieved 2018-04-15.
- ^ Prayson RA, Suh JH (April 1999). "Subependymomas: clinicopathologic study of 14 tumors, including comparative MIB-1 immunohistochemical analysis with other ependymal neoplasms". Archives of Pathology & Laboratory Medicine. 123 (4): 306–309. doi:10.5858/1999-123-0306-S. PMID 10320142.
- ^ Hoeffel C, Boukobza M, Polivka M, Lot G, Guichard JP, Lafitte F, et al. (1995). "MR manifestations of subependymomas". AJNR. American Journal of Neuroradiology. 16 (10): 2121–2129. PMID 8585504.
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