Cannabaceae

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Not to be confused with Serotonin receptor agonist.

A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of serotonin and serotonergic drugs at serotonin (5-HT) receptors.

Types[edit]

5-HT2A antagonists[edit]

Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists).

They include, but are not limited to:

5-HT2A/2C antagonists[edit]

5-HT3 antagonists[edit]

Another subclass consists of drugs selectively acting at the 5-HT3 receptors, and thus are known as 5-HT3 antagonists. They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting.[1]

They include, but are not limited to:

Other 5-HT3 antagonists have been considered for use in the treatment of irritable bowel syndrome:

Also, the antidepressant mirtazapine acts as a 5-HT3 antagonist.

Non-selective 5-HT antagonists[edit]

Although some non-selective serotonin antagonists may have a particular affinity for a specific 5-HT receptor (and thus may be listed below e.g., methysergide), they still may also possess a generalised non-selective action.

They include, but are not limited to:

Antihistamines with antiserotonergic activity[edit]

Others[edit]

  • Fenclonine (para-chlorophenylalanine; PCPA) An inhibitor of serotonin synthesis that has been used in the treatment of carcinoid syndrome.
  • Feverfew[2] Is a herb traditionally used for migraines (contains parthenolide[3]).
  • Reserpine Depletes serotonin stores in the brain, heart, and many other organs and has been used in hypertension and psychosis
  • Gamma-mangostin from Garcinia mangostana[4]

See also[edit]

References[edit]

  1. ^ Lindley, C.; Blower, P. (2000). "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American Journal of Health-System Pharmacy. 57 (18): 1685–1697. doi:10.1093/ajhp/57.18.1685. PMID 11006796.
  2. ^ Pittler MH, Ernst E (2004). Pittler MH (ed.). "Feverfew for preventing migraine". Cochrane Database of Systematic Reviews (1): CD002286. doi:10.1002/14651858.CD002286.pub2. PMID 14973986.
  3. ^ Mittra, S; Datta, A; Singh, SK; Singh, A (December 2000). "5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide content". Acta Pharmacologica Sinica. 21 (12): 1106–14. PMID 11603284.
  4. ^ Chairungsrilerd, Nattaya; Furukawa, K.-I.; Ohta, Tomihisa; Nozoe, Shigeo; Ohizumi, Yasushi (12 December 1997). "γ-Mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist". Naunyn-Schmiedeberg's Archives of Pharmacology. 357 (1): 25–31. doi:10.1007/pl00005134. PMID 9459569. S2CID 24972810.

External links[edit]


source: https://en.wikipedia.org/wiki/Serotonin_antagonism

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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