Cannabaceae

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SOX12
Identifiers
AliasesSOX12, SOX22, SRY-box 12, SRY-box transcription factor 12
External IDsOMIM: 601947; MGI: 98360; HomoloGene: 5057; GeneCards: SOX12; OMA:SOX12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6666

20667

Ensembl

ENSG00000177732

ENSMUSG00000051817

UniProt

O15370

Q04890

RefSeq (mRNA)

NM_006943

NM_011438

RefSeq (protein)

NP_008874

NP_035568

Location (UCSC)Chr 20: 0.33 – 0.33 MbChr 2: 152.24 – 152.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SOX12 is a protein that in humans is encoded by the SOX12 gene.[5][6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177732 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677.
  6. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
  7. ^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825.
  8. ^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418.

Further reading

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source: https://en.wikipedia.org/wiki/SOX12

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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