THC Science

RXRG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GL8
Identifiers
Aliases	RXRG, NR2B3, RXRC, Retinoid X receptor gamma, RXR-gamma, RXRgamma
External IDs	OMIM: 180247; MGI: 98216; HomoloGene: 21373; GeneCards: RXRG; OMA:RXRG - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,445,355 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,467,192 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	6258
	20183
	ENSG00000143171
	ENSMUSG00000015843
	P48443
	P28705
	NM_001256570; NM_001256571; NM_006917
	NM_001159731; NM_009107
	NP_001243499; NP_001243500; NP_008848
	NP_001153203; NP_033133
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.^[5]^[6]

Function[edit]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions[edit]

Retinoid X receptor gamma has been shown to interact with ITGB3BP.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015843 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
^ ^a ^b "Entrez Gene: RXRG retinoid X receptor, gamma".
^ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

Further reading[edit]

Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death Differ. 11 Suppl 2 (S2): S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. S2CID 40617478.
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497.
Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human". Immunogenetics. 41 (2–3): 83–90. doi:10.1007/BF00182317. PMID 7806300. S2CID 29455544.
Muscat GE, Mynett-Johnson L, Dowhan D, Downes M, Griggs R (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMC 307847. PMID 8127707.
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell. 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology. 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002.
Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069. S2CID 24005650.
Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology. 139 (11): 4476–82. doi:10.1210/endo.139.11.6283. PMID 9794455.
Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jcem.86.6.7546. PMID 11397877.
Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH, Kim TS, Lee JW (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene. 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790. S2CID 7377737.
Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.
Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.
Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta. 23 (8–9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685.
Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. doi:10.1042/cs1030613. PMID 12444914.
Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. doi:10.1002/j.1939-4640.2003.tb02649.x. PMID 12514092. S2CID 84798433.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143171 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015843 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8034312-5] Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.

[entrez-6] "Entrez Gene: RXRG retinoid X receptor, gamma".

[pmid11713274-7] Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

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Retinoid receptor modulators
RARTooltip Retinoic acid receptor	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) AC-261066 AC-55649 Acitretin Adapalene all-trans-Retinoic acid (tretinoin) AM-580 BMS-493 BMS-753 BMS-961 CD-1530 CD-2314 CD-437 Ch-55 EC 23 Etretinate Fenretinide Isotretinoin Palovarotene Retinoic acid Retinol (vitamin A) Tamibarotene Tazarotene Tazarotenic acid Trifarotene TTNPB Antagonists: BMS-195614 BMS-493 CD-2665 ER-50891 LE-135 MM-11253 Retinoic acid metabolism inhibitors: Liarozole
RXRTooltip Retinoid X receptor	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) all-trans-Retinoic acid (tretinoin) Bexarotene CD 3254 Docosahexaenoic acid Fluorobexarotene Isotretinoin LG-100268 LG-101506 LG-100754 Retinoic acid Retinol (vitamin A) SR-11237 Antagonists: HX-531 HX-630 LG-100754 PA-452 UVI-3003 HX-603 LE135 (RAR beta selective) LE-540 CD3254 PA-451 PA-452 Rhein HX-711 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
See also Receptor/signaling modulators

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