Cannabaceae

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Propionylation is a post-translational modification of proteins, in which a propionyl-group is added to a lysine amino acid of a protein. Propionylation participates in crucial biological processes, including metabolic processes and cellular stress response.[1]

Lysine propionylation was first identified on histone proteins,[2] and since has also been identified on other proteins.[3] Histone propionylation is a mark of active chromatin.[4] The substrate for protein propionylation is propionyl-CoA. Propionyl-CoA in the cell is metabolised by the enzyme propionyl-CoA carboxylase. Accumulation of propionyl-CoA leads to increased protein propionylation.[5]

In patients with propionic acidemia, a rare autosomal recessive metabolic disorder, propionyl-CoA levels elevated and increased propionylation,[6] which might contribute to the pathology in these patients.[5]

References[edit]

  1. ^ Shui, Ke; Wang, Chenwei; Zhang, Xuedi; Ma, Shanshan; Li, Qinyu; Ning, Wanshan; Zhang, Weizhi; Chen, Miaomiao; Peng, Di; Hu, Hui; Fang, Zheng; Guo, Anyuan; Gao, Guanjun; Ye, Mingliang; Zhang, Luoying (2023-05-17). "Small-sample learning reveals propionylation in determining global protein homeostasis". Nature Communications. 14 (1): 2813. Bibcode:2023NatCo..14.2813S. doi:10.1038/s41467-023-38414-8. ISSN 2041-1723. PMC 10192394. PMID 37198164.
  2. ^ Chen, Y; Sprung, R; Tang, Y; Ball, H; Sangras, B; Kim, SC; Falck, JR; Peng, J; Gu, W; Zhao, Y (May 2007). "Lysine propionylation and butyrylation are novel post-translational modifications in histones". Molecular & Cellular Proteomics. 6 (5): 812–9. doi:10.1074/mcp.M700021-MCP200. PMC 2911958. PMID 17267393.
  3. ^ Cheng, Z; Tang, Y; Chen, Y; Kim, S; Liu, H; Li, SS; Gu, W; Zhao, Y (January 2009). "Molecular characterization of propionyllysines in non-histone proteins". Molecular & Cellular Proteomics. 8 (1): 45–52. doi:10.1074/mcp.M800224-MCP200. PMC 2621001. PMID 18753126.
  4. ^ Kebede, Adam F.; Nieborak, Anna; Shahidian, Lara Zorro; Le Gras, Stephanie; Richter, Florian; Gómez, Diana Aguilar; Baltissen, Marijke P.; Meszaros, Gergo; Magliarelli, Helena de Fatima; Taudt, Aaron; Margueron, Raphael (December 2017). "Histone propionylation is a mark of active chromatin". Nature Structural & Molecular Biology. 24 (12): 1048–1056. doi:10.1038/nsmb.3490. hdl:2066/207705. ISSN 1545-9985. PMID 29058708. S2CID 9788234.
  5. ^ a b Lagerwaard, Bart; Pougovkina, Olga; Bekebrede, Anna F.; Brinke, Heleen; Wanders, Ronald J.A.; Nieuwenhuizen, Arie G.; Keijer, Jaap; Boer, Vincent C. J. (2020-08-17). "Increased protein propionylation contributes to mitochondrial dysfunction in liver cells and fibroblasts, but not in myotubes". Journal of Inherited Metabolic Disease. 44 (2): 438–449. doi:10.1002/jimd.12296. ISSN 0141-8955. PMC 8049071. PMID 32740932.
  6. ^ Pougovkina, Olga; Te Brinke, Heleen; Wanders, Ronald J. A.; Houten, Sander M.; de Boer, Vincent C. J. (September 2014). "Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism". Journal of Inherited Metabolic Disease. 37 (5): 709–714. doi:10.1007/s10545-014-9684-9. ISSN 1573-2665. PMID 24531926. S2CID 26627794.
source: https://en.wikipedia.org/wiki/Propionylation

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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