Cannabaceae

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Posovolone
Clinical data
Other namesCO-134444; Co 134444; V-134444; 3β-Hydroxy-21-(1H-imidazol-1-yl)-3α-(methoxymethyl)-5α-pregnan-20-one
Identifiers
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3-(methoxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-imidazol-1-ylethanone
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC26H40N2O3
Molar mass428.617 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@@](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CN5C=CN=C5)C)(COC)O
  • InChI=1S/C26H40N2O3/c1-24-10-11-26(30,16-31-3)14-18(24)4-5-19-20-6-7-22(25(20,2)9-8-21(19)24)23(29)15-28-13-12-27-17-28/h12-13,17-22,30H,4-11,14-16H2,1-3H3/t18-,19-,20-,21-,22+,24-,25-,26+/m0/s1
  • Key:BRVGKZNQWCQKTC-MVCIVNJCSA-N

Posovolone (developmental code name Co 134444) is a synthetic neurosteroid which was under development as a sedative/hypnotic medication for the treatment of insomnia.[1][2] [3][4] It is orally active and acts as a GABAA receptor positive allosteric modulator.[1][5][2] In animals, posovolone shows anticonvulsant, anxiolytic-like, ataxic, and sleep-promoting effects and appeared to produce effects similar to those of pregnanolone.[2][6] Development of the agent was started by 1999 and appears to have been discontinued by 2007.[1][6] In 2021, an INNTooltip International Nonproprietary Name was registered for posovolone with the descriptor of "antidepressant".[5] Posovolone was originally developed by Purdue Pharma.[1]

See also[edit]

References[edit]

  1. ^ a b c d "CO 134444 - AdisInsight".
  2. ^ a b c Vanover KE, Hogenkamp DJ, Lan NC, Gee KW, Carter RB (May 2001). "Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid". Psychopharmacology (Berl). 155 (3): 285–91. doi:10.1007/s002130100695. PMID 11432691. S2CID 44353086.
  3. ^ Hamilton NM (August 2002). "Interaction of steroids with the GABA(A) receptor". Curr Top Med Chem. 2 (8): 887–902. doi:10.2174/1568026023393570. PMID 12171578.
  4. ^ Belelli D, Hogenkamp D, Gee KW, Lambert JJ (May 2020). "Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor". Neurobiol Stress. 12: 100207. doi:10.1016/j.ynstr.2019.100207. PMC 7231973. PMID 32435660.
  5. ^ a b https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf#page=137 [bare URL PDF]
  6. ^ a b Vanover KE, Edgar DM, Seidel WF, Hogenkamp DJ, Fick DB, Lan NC, Gee KW, Carter RB (December 1999). "Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids". J Pharmacol Exp Ther. 291 (3): 1317–23. PMID 10565857.

External links[edit]


source: https://en.wikipedia.org/wiki/Posovolone

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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