Cannabaceae

PTCH2
Identifiers
AliasesPTCH2, PTC2, patched 2
External IDsOMIM: 603673; MGI: 1095405; HomoloGene: 37842; GeneCards: PTCH2; OMA:PTCH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003738
NM_001166292

NM_008958
NM_001312903

RefSeq (protein)

NP_001159764
NP_003729

NP_001299832
NP_032984

Location (UCSC)n/aChr 4: 116.95 – 116.97 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Patched 2 is a protein that in humans is encoded by the PTCH2 gene.[4]

Function

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This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway.[4]

Clinical significance

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Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia.[4]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028681Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b c "Entrez Gene: Patched 2".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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