Cannabaceae

thcscience_admin
PNRC1
Identifiers
AliasesPNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDsOMIM: 606714; MGI: 1917838; HomoloGene: 4960; GeneCards: PNRC1; OMA:PNRC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10957

108767

Ensembl

ENSG00000146278

ENSMUSG00000040128

UniProt

Q12796
Q49A59

Q3TWH3

RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC)Chr 6: 89.08 – 89.09 MbChr 4: 33.25 – 33.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[5][6]

Function[edit]

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146278 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040128 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
  6. ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
  7. ^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
  8. ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading[edit]

External links[edit]


source: https://en.wikipedia.org/wiki/PNRC1

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

Leave a Reply