Cannabaceae

PHF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPHF1, MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1
External IDsOMIM: 602881; MGI: 98647; HomoloGene: 7567; GeneCards: PHF1; OMA:PHF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002636
NM_024165

NM_009343
NM_001302397

RefSeq (protein)

NP_002627
NP_077084

NP_001289326
NP_033369

Location (UCSC)Chr 6: 33.41 – 33.42 MbChr 17: 27.15 – 27.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[5][6][7]

Function

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This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[7]

References

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  1. ^ a b c ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024193Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646.
  6. ^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154.
  7. ^ a b "Entrez Gene: PHF1 PHD finger protein 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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