An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants.[1] In particular, both the researchers and participants know which treatment is being administered.[1] This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias.[2][3]
Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants,[4] or possible relief from symptoms of some disorders when a placebo is given.[5]
An open-label trial may still be randomized. Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment.[4]
References[edit]
- ^ a b "Open label study". National Cancer Institute, US National Institutes of Health. 2020. Retrieved 20 November 2020.
- ^ "Double-blind (trial)". Merriam-Webster Medical Dictionary. 2020. Retrieved 20 November 2020.
- ^ "Double-blind study". HIV.gov, Office of AIDS Research, US National Institutes of Health. 2020. Retrieved 20 November 2020.
- ^ a b Beyer-Westendorf, J.; Buller, H. (2011). "External and internal validity of open label or double-blind trials in oral anticoagulation: better, worse or just different?". Journal of Thrombosis and Haemostasis. 9 (11): 2153–2158. doi:10.1111/j.1538-7836.2011.04507.x. ISSN 1538-7933. PMID 21920015.
- ^ Ballou, Sarah; Kaptchuk, Ted J.; Hirsch, William; Nee, Judy; Iturrino, Johanna; Hall, Kathryn T.; Kelley, John M.; Cheng, Vivian; Kirsch, Irving; Jacobson, Eric; Conboy, Lisa; Lembo, Anthony; Davis, Roger B. (25 May 2017). "Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial". Trials. 18 (1): 234. doi:10.1186/s13063-017-1964-x. ISSN 1745-6215. PMC 5445390. PMID 28545508.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction