Cannabaceae

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Olanzapine/fluoxetine
Combination of
OlanzapineAtypical antipsychotic
FluoxetineSelective serotonin reuptake inhibitor
Clinical data
Trade namesSymbyax, Cinol Forte, Olapin Forte, others
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
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Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder[2] as well as treatment-resistant depression.[1][3]

Medical uses[edit]

Olanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003.[1] In 2009, it was granted approval for the treatment of treatment-resistant depression.[4]

Olanzapine/fluoxetine, or other antidepressant/antipsychotic combinations, are sometimes prescribed off-label for anxiety disorders,[5] eating disorders,[6] obsessive–compulsive disorder (OCD),[7] and posttraumatic stress disorder (PTSD).[8]

Side effects[edit]

Possible side effects of olanzapine/fluoxetine include all those of the two component drugs: olanzapine (side effects) and fluoxetine (side effects). Common side effects include suicidal thoughts, increased appetite, weight gain, drowsiness, fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating.[1]

Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine.[9]

Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring.[9]

In rare cases, olanzapine/fluoxetine may cause neuroleptic malignant syndrome.[1]

Like other SSRIs, olanzapine/fluoxetine carries a boxed warning stating that it could increase the risk of suicidal thoughts and behaviors in patients aged 24 and under. The warning also states that olanzapine/fluoxetine may increase the risk of death in elderly patients with dementia-related psychosis.[1]

See also[edit]

References[edit]

  1. ^ a b c d e f "Symbyax- olanzapine and fluoxetine hydrochloride capsule". DailyMed. 21 April 2020. Retrieved 30 September 2020.
  2. ^ "Tratamento medicamentoso dos transtornos bipolares - Transtornos psiquiátricos". Manuais MSD edição para profissionais (in Brazilian Portuguese). Retrieved 2022-10-02.
  3. ^ Benazzi F, Berk M, Frye MA, Wang W, Barraco A, Tohen M (October 2009). "Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis". The Journal of Clinical Psychiatry. 70 (10): 1424–1431. doi:10.4088/JCP.08m04772gre. PMID 19906346.
  4. ^ Grohol, J. "FDA Approves Symbyax for Treatment Resistant Depression". Psych Central Blog. Archived from the original on 2017-12-26. Retrieved 2010-07-17.
  5. ^ McIntyre R, Katzman M (2003). "The role of atypical antipsychotics in bipolar depression and anxiety disorders". Bipolar Disorders. 5 (Suppl 2): 20–35. doi:10.1111/j.1399-2406.2003.00061.x. PMID 14700010.
  6. ^ Pederson KJ, Roerig JL, Mitchell JE (October 2003). "Towards the pharmacotherapy of eating disorders". Expert Opinion on Pharmacotherapy. 4 (10): 1659–1678. doi:10.1517/14656566.4.10.1659. PMID 14521477. S2CID 38506292.
  7. ^ Koran LM, Ringold AL, Elliott MA (July 2000). "Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder". The Journal of Clinical Psychiatry. 61 (7): 514–517. doi:10.4088/JCP.v61n0709. PMID 10937610.
  8. ^ Stein MB, Kline NA, Matloff JL (October 2002). "Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study". The American Journal of Psychiatry. 159 (10): 1777–1779. doi:10.1176/appi.ajp.159.10.1777. PMID 12359687.
  9. ^ a b "Symbyax". Drugs.com.

External links[edit]

source: https://en.wikipedia.org/wiki/Olanzapine/fluoxetine

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
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