Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]
Human Oct proteins[edit]
- Oct-1 - POU2F1
- Oct-2 - POU2F2
- Oct-3/4 – POU5F1
- Oct-6 – POU3F1
- Oct-7 – POU3F2
- Oct-8 – POU3F3
- Oct-9 – POU3F4
- Oct-11 – POU2F3
References[edit]
- ^ Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB (1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. Bibcode:1990PNAS...87.1099P. doi:10.1073/pnas.87.3.1099. PMC 53418. PMID 1967834.
- ^ Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
- ^ a b c d e Zhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions". Frontiers in Bioscience (Landmark Edition). 18 (3): 1051–71. doi:10.2741/4162. PMC 4349413. PMID 23747866.
External links[edit]
- Octamer+transcription+factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
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