Cannabaceae

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Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron)

Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants.[1] They act by antagonizing the α2-adrenergic receptor and certain serotonin receptors such as 5-HT2A and 5-HT2C,[1] but also 5-HT3,[1] 5-HT6, and/or 5-HT7 in some cases. By blocking α2-adrenergic autoreceptors and heteroreceptors, NaSSAs enhance adrenergic and serotonergic neurotransmission in the brain involved in mood regulation,[1] notably 5-HT1A-mediated transmission.[2] In addition, due to their blockade of certain serotonin receptors, serotonergic neurotransmission is not facilitated in unwanted areas, which prevents the incidence of many side effects often associated with selective serotonin reuptake inhibitor (SSRI) antidepressants;[1][3] hence, in part, the "specific serotonergic" label of NaSSAs.[2]

List of NaSSAs[edit]

The NaSSAs include the following agents:

Notably, all of these compounds are analogues and are also classified as tetracyclic antidepressants (TeCAs) based on their chemical structures.

S32212, a structurally novel NaSSA with an improved selectivity profile (e.g., no antihistamine effects, etc.), was reported in 2012.[5][6] It has completed preliminary preclinical research and may go on to undergo clinical trials.

See also[edit]

References[edit]

  1. ^ a b c d e Robert M. Julien (17 September 2004). A Primer Of Drug Action: A Comprehensive Guide To The Actions, Uses, And Side Effects Of Psychoactive Drugs. Macmillan. p. 286. ISBN 978-0-7167-0615-1. Retrieved 23 April 2012.
  2. ^ a b Robert E. Hales; Narriman C. Shahrokh; Alan F. Schatzberg; Charles B. Nemeroff (28 April 2009). Study Guide to Psychopharmacology: A Companion to the American Psychiatric Publishing Textbook of Psychopharmacology, Fourth Edition. American Psychiatric Pub. p. 202. ISBN 978-1-58562-354-9. Retrieved 23 April 2012.
  3. ^ Bentham Science Publishers (August 1998). Current Pharmaceutical Design. Bentham Science Publishers. p. 298. Retrieved 23 April 2012.
  4. ^ a b Roland A. Carlstedt (14 December 2009). Handbook of Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine: Perspectives, Practices, and Research. Springer Publishing Company. p. 290. ISBN 978-0-8261-1094-7. Retrieved 23 April 2012.
  5. ^ Millan MJ, Mannoury la Cour C, Chanrion B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 750–64. doi:10.1124/jpet.111.187468. PMID 22178752. S2CID 8546314.
  6. ^ Dekeyne A, Brocco M, Loiseau F, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 765–80. doi:10.1124/jpet.111.187534. PMID 22178753. S2CID 11363664.

Further reading[edit]

External links[edit]

source: https://en.wikipedia.org/wiki/Noradrenergic_and_specific_serotonergic_antidepressant

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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