| Combination of | |
|---|---|
| Neostigmine | Cholinesterase inhibitor |
| Glycopyrronium bromide | Antimuscarinic agent |
| Clinical data | |
| Trade names | Prevduo |
| Other names | Neostigmine methylsulfate/glycopyrrolate, glycopyrronium bromide/neostigmine metilsulfate |
| License data | |
| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
Neostigmine/glycopyrronium bromide, sold under the brand name Prevduo , is a fixed-dose combination medication used for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery.[2] It contains neostigmine as the methylsulfate, a cholinesterase inhibitor, and glycopyrronium bromide, an antimuscarinic agent.[2]
Neostigmine/glycopyrronium bromide was approved for medical use in the United Kingdom in 2007,[1] and in the United States in February 2023.[3]
Medical uses[edit]
Neostigmine/glycopyrronium bromide is indicated for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery, while decreasing the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) associated with cholinesterase inhibition following non-depolarizing neuromuscular blocking agent reversal administration.[3]
References[edit]
- ^ a b "Glycopyrronium Bromide and Neostigmine Metilsulfate 0.5mg/2.5mg per ml Solution for Injection - Summary of Product Characteristics (SmPC)". (emc). 12 November 2018. Archived from the original on 7 August 2022. Retrieved 25 February 2023.
- ^ a b c "Archived copy" (PDF). Archived (PDF) from the original on 26 February 2023. Retrieved 25 February 2023.
{{cite web}}: CS1 maint: archived copy as title (link) - ^ a b https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2023/216903Orig1s000ltr.pdf Archived 26 February 2023 at the Wayback Machine
This article incorporates text from this source, which is in the public domain.
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