In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils, spleen, and primary lymphoid follicles in lymph nodes.
Once exposed to an antigen, the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. Plasma cells do not last long in the circulation; this is in contrast to memory cells that last for very long periods of time. Memory cells do not secrete antibodies until activated by their specific antigen. [1][2]
Naive B cells play a key role in predicting humoral responses to COVID-19 mRNA vaccines in immunocompromised patients, specifically measuring naive B cell levels could help predict and improve vaccination outcomes.[3]
Notes and references
[edit]- ^ Airoldi I, Raffaghello L, Cocco C, et al. (January 2004). "Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes". Clin. Cancer Res. 10 (1 Pt 1): 144–54. doi:10.1158/1078-0432.CCR-1026-3. PMID 14734463. S2CID 1413735.
- ^ Lang ML (Aug 2009). "How do natural killer T cells help B cells?". Expert Rev Vaccines. 8 (8): 1109–21. doi:10.1586/erv.09.56. PMC 2747240. PMID 19627191.
- ^ Herishanu, Yair; Avivi, Irit; Aharon, Adi; Shefer, Galia; Itchaki, Gilad; Bavli, Shani; Neiman, Dorit; Herzig, Eli; Faitovich, Asaf; Tepper, Ronit; Ziv-Baran, Tamar; Ronen, Ronit; Benjamini, Ofer; Paul, Sarah; Hagin, Dekel; Raanani, Pesach; Gover-Proaktor, Adi (2021-08-11). "Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with B-cell chronic lymphocytic leukemia". medRxiv. doi:10.1101/2021.08.11.21261898.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction