Cannabaceae

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Mipafox
Names
Preferred IUPAC name
N,N′-Di(propan-2-yl)phosphorodiamidic fluoride
Other names
Bis(isopropylamino)fluorophosphine oxide; Isopestox
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.006.130 Edit this at Wikidata
EC Number
  • 206-742-3
KEGG
UNII
  • InChI=1S/C6H16FN2OP/c1-5(2)8-11(7,10)9-6(3)4/h5-6H,1-4H3,(H2,8,9,10)
    Key: UOSHUBFBCPGQAY-UHFFFAOYSA-N
  • CC(C)NP(=O)(NC(C)C)F
Properties
C6H16FN2OP
Molar mass 182.179 g·mol−1
Density 1.2
Melting point 65 °C (149 °F; 338 K)
Boiling point 125 °C (257 °F; 398 K)
80 g/L
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Highly toxic
GHS labelling:
GHS06: ToxicGHS07: Exclamation mark
Danger
H301, H370
P260, P264, P270, P301+P310, P307+P311, P321, P330, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Mipafox is a highly toxic organophosphate insecticide that is an irreversible acetylcholinesterase inhibitor and is resistant to cholinesterase reactivators.[1] It was developed in the 1950s and is now believed to be no longer in use.[2]

Toxicity[edit]

There are case reports of delayed neurotoxicity and paralysis due to acute exposure to mipafox.[3]

Synthesis[edit]

Phosphoryl chloride is first reacted with isopropylamine. The resulting product is then reacted with potassium fluoride or ammonium fluoride to produce mipafox.[4]

See also[edit]

References[edit]

  1. ^ Mangas, I; Taylor, P; Vilanova, E; Estévez, J; França, TC; Komives, E; Radić, Z (March 2016). "Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches". Archives of Toxicology. 90 (3): 603–16. doi:10.1007/s00204-015-1481-1. PMC 4833118. PMID 25743373.
  2. ^ "The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019" (PDF). World Health Organization.
  3. ^ BIDSTRUP, PL; BONNELL, JA; BECKETT, AG (16 May 1953). "Paralysis following poisoning by a new organic phosphorus insecticide (mipafox); report on two cases". British Medical Journal. 1 (4819): 1068–72. doi:10.1136/bmj.1.4819.1068. PMC 2016450. PMID 13042137.
  4. ^ "Process for the preparation of bisisopropyl-amino-fluoro-phosphine oxide".


source: https://en.wikipedia.org/wiki/Mipafox

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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