Cannabaceae

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ADAMTS8
Identifiers
AliasesADAMTS8, ADAM-TS8, METH2, ADAM metallopeptidase with thrombospondin type 1 motif 8
External IDsOMIM: 605175; MGI: 1353468; HomoloGene: 5108; GeneCards: ADAMTS8; OMA:ADAMTS8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

11095

30806

Ensembl

ENSG00000134917

ENSMUSG00000031994

UniProt

Q9UP79

P57110

RefSeq (mRNA)

NM_007037

NM_013906
NM_001326292

RefSeq (protein)

NP_008968

NP_038934.2

Location (UCSC)Chr 11: 130.4 – 130.43 MbChr 9: 30.85 – 30.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[5][6]

Function[edit]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[6]

Clinical significance[edit]

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134917 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031994 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
  6. ^ a b c "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


source: https://en.wikipedia.org/wiki/Meth-2

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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