Cannabaceae

MXD3
Identifiers
AliasesMXD3, BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDsOMIM: 609450; MGI: 104987; HomoloGene: 32333; GeneCards: MXD3; OMA:MXD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031300
NM_001142935
NM_001394986
NM_001394987

NM_016662

RefSeq (protein)

NP_001136407
NP_112590
NP_112590.1

NP_057871

Location (UCSC)Chr 5: 177.3 – 177.31 MbChr 13: 55.47 – 55.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.[5][6]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.[7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213347Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021485Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
  6. ^ a b "Entrez Gene: MXD3 MAX dimerization protein 3".
  7. ^ Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.
  8. ^ Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. Bibcode:2012PLoSO...738508B. doi:10.1371/journal.pone.0038508. PMC 3393725. PMID 22808009.

One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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