Cannabaceae

MX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDsOMIM: 147150; MGI: 97244; HomoloGene: 1844; GeneCards: MX1; OMA:MX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144925
NM_001178046
NM_001282920
NM_002462

NM_013606

RefSeq (protein)

NP_001138397
NP_001171517
NP_001269849
NP_002453

NP_038634

Location (UCSC)Chr 21: 41.42 – 41.47 MbChr 16: 97.34 – 97.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[5][6]

In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major determinant for influenza viruses of animal origin.[7] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157601Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023341Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–8. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
  6. ^ a b "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".
  7. ^ Ciminski, Kevin; Chase, Geoffrey; Beer, Martin; Schwemmle, Martin (2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.

Further reading[edit]


One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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