Cannabaceae

MMPIP
Identifiers
  • 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H19N3O3
Molar mass337.379 g·mol−1
3D model (JSmol)
  • COc3ccc(cc3)C2CC(C1C(=O)N2C)ON=C1c4ccncc4
  (verify)

MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7.[1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain.[2]

References[edit]

  1. ^ Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420. S2CID 10402176.
  2. ^ Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology. 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMC 3739975. PMID 19158667.


One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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