Monoclonal antibody | |
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Type | Whole antibody |
Source | Human |
Target | TRAIL-R2 |
Clinical data | |
ATC code |
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Identifiers | |
CAS Number | |
ChemSpider |
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UNII | |
KEGG | |
Chemical and physical data | |
Formula | C6346H9832N1720O2002S42 |
Molar mass | 143601.02 g·mol−1 |
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Lexatumumab (also known as ETR2-ST01) is an experimental agonistic human monoclonal antibody against TRAIL-R2 (DR5, APO-2), intended for the treatment of cancer.[1][2]
HGS-ETR2 antibodies were generated by Human Genome Sciences through a collaboration with Cambridge Antibody Technology.[3]
Development was discontinued in 2015.[4]
References
[edit]- ^ "Statement on a Nonproprietary Name adopted by the USAN Council - Lexatumumab" (PDF). American Medical Association. Archived from the original (PDF) on 2012-02-20.
- ^ Marini P (December 2006). "Drug evaluation: lexatumumab, an intravenous human agonistic mAb targeting TRAIL receptor 2". Current Opinion in Molecular Therapeutics. 8 (6): 539–46. PMID 17243490.
- ^ "TRAIL Receptor Antibodies". Human Genome Sciences, Inc. Archived from the original on 2008-05-16. Retrieved 2010-05-12.
- ^ "Lexatumumab". AdisInsight. Springer Nature Switzerland AG.
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