Cannabaceae

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LY-393558
Identifiers
  • 1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl)ethyl)-3-isopropyl-6-(methylsulfonyl)-3,4-dihydro-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H31FN4O4S2
Molar mass546.68 g·mol−1
3D model (JSmol)
  • FC1=CC=C2C(NC=C2C3=CCN(CCN4S(N(C(C)C)CC5=C4C=CC(S(=O)(C)=O)=C5)(=O)=O)CC3)=C1
  • InChI=1S/C26H31FN4O4S2/c1-18(2)31-17-20-14-22(36(3,32)33)5-7-26(20)30(37(31,34)35)13-12-29-10-8-19(9-11-29)24-16-28-25-15-21(27)4-6-23(24)25/h4-8,14-16,18,28H,9-13,17H2,1-3H3
  • Key:QUSLYAPLTMMCFE-UHFFFAOYSA-N

LY-393558 is a potent serotonin reuptake inhibitor and antagonist of the 5-HT1B, 5-HT1D, and 5-HT2A receptors. LY-393558 was also found to reduce serotonin-induced vasoconstriction, indicating that it may have therapeutic potential for the treatment of pulmonary hypertension.[1][2]

References[edit]

  1. ^ Mitchell SN, Greenslade RG, Cooper J (November 2001). "LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat". European Journal of Pharmacology. 432 (1): 19–27. doi:10.1016/S0014-2999(01)01469-8. PMID 11734183.
  2. ^ Baranowska-Kuczko M, Kozłowska H, Schlicker E, Göthert M, MacLean MR, Kozłowski M, et al. (June 2020). "Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558". Pharmacological Reports. 72 (3): 756–762. doi:10.1007/s43440-020-00105-2. PMC 7329800. PMID 32333296.



source: https://en.wikipedia.org/wiki/LY-393558

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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