Cannabaceae

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L-765,314
Identifiers
  • benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC27H34N6O5
Molar mass522.606 g·mol−1
3D model (JSmol)
  • CC(C)(C)NC(=O)[C@@H]1CN(CCN1C(=O)OCc2ccccc2)c3nc4cc(c(cc4c(n3)N)OC)OC
  • InChI=1S/C27H34N6O5/c1-27(2,3)31-24(34)20-15-32(11-12-33(20)26(35)38-16-17-9-7-6-8-10-17)25-29-19-14-22(37-5)21(36-4)13-18(19)23(28)30-25/h6-10,13-14,20H,11-12,15-16H2,1-5H3,(H,31,34)(H2,28,29,30)/t20-/m0/s1 ☒N
  • Key:CGWOIDCAGBKOQL-FQEVSTJZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-765,314 is a drug which acts as a potent and selective antagonist of the α1-adrenergic receptor subtype α1B.[1] It has mainly been used to investigate the role of α1B-adrenergic receptors in the regulation of blood pressure.[2][3] The α1B receptor is also thought to have an important role in the brain; however, L-765,314 does not cross the blood–brain barrier.[4]

References[edit]

  1. ^ Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG (April 1998). "4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist ". Journal of Medicinal Chemistry. 41 (8): 1205–8. doi:10.1021/jm980053f. PMID 9548811.
  2. ^ Yang XP, Chiba S (August 2002). "Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries". Japanese Journal of Pharmacology. 89 (4): 429–32. doi:10.1254/jjp.89.429. PMID 12233824.
  3. ^ Görnemann T, Villalón CM, Centurión D, Pertz HH (June 2009). "Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors". European Journal of Pharmacology. 613 (1–3): 86–92. doi:10.1016/j.ejphar.2009.04.011. PMID 19376108.
  4. ^ Hillman KL, Doze VA, Porter JE (June 2007). "Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus". The Journal of Pharmacology and Experimental Therapeutics. 321 (3): 1062–8. doi:10.1124/jpet.106.119297. PMID 17337632. S2CID 8780600.



source: https://en.wikipedia.org/wiki/L-765,314

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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