Cannabaceae

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Kaempferide
Kaempferide structure
Names
IUPAC name
3,5,7-Trihydroxy-4′-methoxyflavone
Systematic IUPAC name
3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Other names
Kaempferid
4′-Methylkaempferol
Kaempferol 4′-methyl ether
4′-O-Methylkaempferol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.007.036 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 ☒N
    Key: SQFSKOYWJBQGKQ-UHFFFAOYSA-N ☒N
  • InChI=1/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
    Key: SQFSKOYWJBQGKQ-UHFFFAOYAC
  • COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
  • COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Properties
C16H12O6
Molar mass 300.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.[1]

Metabolism

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The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.

Glycosides

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Icariin is the tert-amyl alcohol derivative of kaempferide 3,7-O-diglycoside.

References

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  1. ^ Lee, Jungwhoi; Kim, Jae Hoon (2016). "Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro". PLOS ONE. 11 (5): e0155264. Bibcode:2016PLoSO..1155264L. doi:10.1371/journal.pone.0155264. PMC 4866780. PMID 27175782.
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source: https://en.wikipedia.org/wiki/Kaempferide

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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