THC Science

Iron(III) pyrophosphate
Names
	Other names Ferric pyrophosphate
Identifiers
CAS Number	10058-44-3 (anhydrous); 10049-18-0 (nonahydrate); 1802359-96-1;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:132767;
ChemSpider	23258; 34994433;
DrugBank	DB09147; DB13995;
ECHA InfoCard	100.030.160
EC Number	233-190-0;
PubChem CID	24877;
UNII	QK8899250F; 1ZJR117WBQ (nonahydrate); UBY79OCO9G;
CompTox Dashboard (EPA)	DTXSID6047600 ;
	InChI Key: CADNYOZXMIKYPR-UHFFFAOYSA-B; InChI=1S/4Fe.3H4O7P2/c;;;;31-8(2,3)7-9(4,5)6/h;;;;3(H2,1,2,3)(H2,4,5,6)/q4*+3;;;/p-12;
	SMILES [Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3];
Properties
Chemical formula	Fe4(P2O7)3
Molar mass	745.224 (anhydrate); 907.348 (nonahydrate)
Appearance	yellow solid (nonahydrate)
Solubility in water	insoluble
Pharmacology
Legal status	CA: ℞-only; US: ℞-only;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Iron(III) pyrophosphate is an inorganic chemical compound with the formula Fe₄(P₂O₇)₃.

Synthesis[edit]

Anhydrous iron(III) pyrophosphate can be prepared by heating the mixture of iron(III) metaphosphate and iron(III) phosphate under oxygen with the stoichiometric ratio 1:3. The reactants can be prepared by reacting iron(III) nitrate nonahydrate with phosphoric acid.^[5]

It can be also prepared via the following reaction:^[6]

3 Na₄P₂O₇(aq) + 4 FeCl₃(aq) → Fe₄(P₂O₇)₃(s) + 12 NaCl(aq)

^ W.M.Haynes. CRC Handbook of Chemistry and Physics (97th edition). New York: CRC Press, 2016. pp 4-68
^ "Summary Basis of Decision (SBD) for Triferic Avnu". Health Canada. 23 October 2014. Retrieved 29 May 2022.
^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
^ "Triferic Avnu- ferric pyrophosphate citrate solution". DailyMed. 15 September 2020. Retrieved 29 May 2022.
^ Elbouaanani, L.K; Malaman, B; Gérardin, R; Ijjaali, M (2002). "Crystal Structure Refinement and Magnetic Properties of Fe4(P2O7)3 Studied by Neutron Diffraction and Mössbauer Techniques". Journal of Solid State Chemistry. 163 (2). Elsevier BV: 412–420. Bibcode:2002JSSCh.163..412E. doi:10.1006/jssc.2001.9415. ISSN 0022-4596.
^ Rossi L, Velikov KP, Philipse AP (May 2014). "Colloidal iron(III) pyrophosphate particles". Food Chem. 151: 243–7. doi:10.1016/j.foodchem.2013.11.050. PMID 24423528.

"Ferric pyrophosphate nonahydrate". Drug Information Portal. U.S. National Library of Medicine.
"Ferric pyrophosphate citrate". Drug Information Portal. U.S. National Library of Medicine.