| Combination of | |
|---|---|
| Ipratropium bromide | Muscarinic antagonist |
| Salbutamol | Short-acting β2-adrenergic agonist |
| Clinical data | |
| Trade names | Combivent, Duoneb, Breva, others |
| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a601063 |
| License data | |
| Routes of administration | Inhalation |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| (verify) | |
Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][4][5] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1]
Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[6][1]
The combination was approved for medical use in the United States in 1996.[7] It is available as a generic medication.[4] In 2021, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions.[8][9]
Medical uses
[edit]Ipratropium bromide/salbutamol can be used for the treatment of COPD[5] and asthma.[10]
Society and culture
[edit]Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to depletion of the ozone layer.[11]
References
[edit]- ^ a b c d e f "Combivent Respimat- ipratropium bromide and albuterol spray, metered". DailyMed. 24 January 2022. Retrieved 30 October 2022.
- ^ "DuoNeb". DailyMed. Retrieved 30 October 2022.
- ^ "Combivent (ipratropium bromide and albuterol sulfate) Inhalation Aerosol". DailyMed. Retrieved 30 October 2022.
- ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
- ^ a b Gordon J, Panos RJ (March 2010). "Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease". Expert Opinion on Drug Metabolism & Toxicology. 6 (3): 381–92. doi:10.1517/17425251003649549. PMID 20163324. S2CID 31806856.
- ^ "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- ^ "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Albuterol; Ipratropium - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, et al. (April 2016). "Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial". BMC Pulmonary Medicine. 16 (1): 65. doi:10.1186/s12890-016-0223-3. PMC 4851785. PMID 27130202.
- ^ "Phase Out of Combivent Inhalation Aerosol - Questions and Answers". FDA. 3 November 2018.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction