Cannabaceae


HLF
Identifiers
AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDsOMIM: 142385; MGI: 96108; HomoloGene: 31074; GeneCards: HLF; OMA:HLF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

Location (UCSC)Chr 17: 55.26 – 55.33 MbChr 11: 90.23 – 90.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

Function[edit]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108924Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003949Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. Bibcode:1992Sci...257..531I. doi:10.1126/science.1386162. PMID 1386162.
  6. ^ a b "Entrez Gene: HLF hepatic leukemia factor".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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