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Names | |
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Preferred IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid | |
Other names
HEPPS, EPPS
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.036.528 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C9H20N2O4S | |
Molar mass | 252.33 g·mol−1 |
Melting point | (decomposes) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.[1]
Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[2][3][4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.[5][6][7]
See also
[edit]References
[edit]- ^ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.
- ^ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.
- ^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. Bibcode:2015NatCo...6.8997K. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
- ^ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.
- ^ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4): eaav1388. Bibcode:2019SciA....5.1388K. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMC 6469948. PMID 31001580.
- ^ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined". Analysis & Separations from Technology Networks. Retrieved 2019-09-30.
- ^ "A possible blood test for early-stage Alzheimer's disease". medicalxpress.com. Retrieved 2019-09-30.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
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