Cannabaceae

GDA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH
External IDsOMIM: 139260; MGI: 95678; HomoloGene: 3171; GeneCards: GDA; OMA:GDA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010266

RefSeq (protein)

NP_034396

Location (UCSC)Chr 9: 72.11 – 72.26 MbChr 19: 21.37 – 21.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[5][6][7] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[8]

Xanthine synthesis from guanine

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119125Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058624Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. Bibcode:1944PNAS...30..294H. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
  6. ^ Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. doi:10.1016/S0021-9258(17)30999-7. PMID 20285041.
  7. ^ Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. doi:10.1016/S0021-9258(18)65881-8. PMID 13278325.
  8. ^ Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.

External links[edit]


One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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