| glycerol kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 glycerol kinase dimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.30 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
| glycerol kinase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GK | ||||||
| NCBI gene | 2710 | ||||||
| HGNC | 4289 | ||||||
| OMIM | 300474 | ||||||
| RefSeq | NM_000167 | ||||||
| UniProt | P32189 | ||||||
| Other data | |||||||
| EC number | 2.7.1.30 | ||||||
| Locus | Chr. X p21.3 | ||||||
| |||||||
Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.
Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate:
- ATP + glycerol <=> ADP + sn-glycerol 3-phosphate
Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:
- Phosphorylated by glycerol kinase to glycerol 3-phosphate.
- Converted from glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP) via glycerol 3-phosphate dehydrogenase. DHAP can participate in glycolysis or gluconeogenesis.
Enzyme regulation[edit]
This protein may use the morpheein model of allosteric regulation.[1]
Structure[edit]
Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a ribonuclease H-like fold consisting of an alpha-beta 2-layer sandwich of CATH family 3.30.420.40. As of March 2010[update], there were 20 structures of this protein in the PDB, most of which are homodimeric.
See also[edit]
External links[edit]
- Glycerol+Kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
References[edit]
- ^ Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo-oligomers and the control of protein function". Archives of Biochemistry and Biophysics. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction