Cannabaceae

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γ-Melanocyte-stimulating hormone
Names
IUPAC name
L-Tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalaninamide
Other names
gamma-MSH, γ-melanotropin, γ-melanocortin, γ-intermedin
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C74H99N21O16S/c1-41(2)62(95-63(102)49(75)30-44-22-24-47(96)25-23-44)72(111)90-53(26-29-112-3)64(103)84-38-59(97)87-57(34-46-37-80-40-86-46)70(109)92-55(32-43-16-8-5-9-17-43)68(107)88-52(21-13-28-82-74(78)79)67(106)93-56(33-45-36-83-50-19-11-10-18-48(45)50)69(108)94-58(35-60(98)99)71(110)89-51(20-12-27-81-73(76)77)66(105)91-54(65(104)85-39-61(100)101)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,83,96H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H,80,86)(H,84,103)(H,85,104)(H,87,97)(H,88,107)(H,89,110)(H,90,111)(H,91,105)(H,92,109)(H,93,106)(H,94,108)(H,95,102)(H,98,99)(H,100,101)(H4,76,77,81)(H4,78,79,82)/t49-,51-,52+,53-,54-,55-,56-,57-,58-,62-/m0/s1
    Key: GZWUQPQBOGLSIM-XEMHBVLISA-N
  • CC(C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)[C@H](CC6=CC=C(C=C6)O)N
Properties
C74H99N21O16S
Molar mass 1570.80 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide.[1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).[1] It is an agonist of the MC1, MC3, MC4, and MC5 receptors.[1] It exists in three forms, γ1-MSH, γ2-MSH, and γ3-MSH.[2]

γ-MSH regulated cardiovascular functions. γ-MSH effects are measured through the effects it has on the central neural pathway dispersed throughout the kidney.[3] It is not moderated based on tubular sodium transport. Gamma-MSH activates MC3R in renal tubular cells by limiting sodium absorption by inhibiting the central neural pathway.[3] This regulates sodium balance and blood pressure. If MC3R is absent then there is resistance in γ-MSH which results in hypertension on HSD.[4]

See also

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References

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  1. ^ a b c Kastin A (26 January 2013). Handbook of Biologically Active Peptides. Academic Press. pp. 838–844. ISBN 978-0-12-385096-6.
  2. ^ Jakubke HD, Sewald N (8 September 2008). Peptides from A to Z: A Concise Encyclopedia. John Wiley & Sons. pp. 216–. ISBN 978-3-527-62117-0.
  3. ^ a b Kathpalia PP, Charlton C, Rajagopal M, Pao AC (May 2011). "The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone". Peptides. 32 (5): 1068–1072. doi:10.1016/j.peptides.2011.02.006. PMC 3112371. PMID 21335042.
  4. ^ Reudelhuber TL (April 2003). "Salt-sensitive hypertension: if only it were as simple as rocket science". The Journal of Clinical Investigation. 111 (8): 1115–1116. doi:10.1172/jci200316993. PMC 152948. PMID 12697727.
source: https://en.wikipedia.org/wiki/Gamma-Melanocyte-stimulating_hormone

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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