Protein-coding gene in the species Homo sapiens
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene .[5] [6]
Interactions [ edit ] GTF2H4 has been shown to interact with:
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000213780 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001524 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH" . EMBO J . 16 (5): 1093–102. doi :10.1093/emboj/16.5.1093 . PMC 1169708 PMID 9118947 . ^ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa" .^ a b c d e Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . ^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A" . Nat. Genet . 36 (7): 714–9. doi :10.1038/ng1387 PMID 15220921 .
Further reading [ edit ]
Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci . 5 (1): 24–7. doi :10.1007/BF02253352 . PMID 9570510 . Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation" . Curr. Biol . 8 (13): R447-9. Bibcode :1998CBio....8.R447Y . doi :10.1016/S0960-9822(98)70289-1 PMID 9651670 . S2CID 15480646 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain" . Mol. Cell. Biol . 16 (5): 2044–55. doi :10.1128/MCB.16.5.2044 . PMC 231191 PMID 8628270 . Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes" . Proc. Natl. Acad. Sci. U.S.A . 93 (13): 6488–93. Bibcode :1996PNAS...93.6488D . doi :10.1073/pnas.93.13.6488 PMC 39050 PMID 8692842 . Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science . 274 (5287): 605–10. Bibcode :1996Sci...274..605Z . doi :10.1126/science.274.5287.605 . PMID 8849451 . S2CID 13266489 . Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature . 384 (6607): 375–8. Bibcode :1996Natur.384..375P . doi :10.1038/384375a0 . PMID 8934526 . S2CID 4278432 . García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes" . J. Biol. Chem . 272 (11): 6951–8. doi :10.1074/jbc.272.11.6951 PMID 9054383 . Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme" . Mol. Cell. Biol . 17 (4): 1817–23. doi :10.1128/mcb.17.4.1817 . PMC 232028 PMID 9121429 . Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH" . EMBO J . 16 (7): 1628–37. doi :10.1093/emboj/16.7.1628 . PMC 1169767 PMID 9130708 . Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription" . EMBO J . 16 (10): 2836–50. doi :10.1093/emboj/16.10.2836 . PMC 1169892 PMID 9184228 . Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity" . J. Virol . 71 (10): 7436–41. doi :10.1128/JVI.71.10.7436-7441.1997 . PMC 192089 PMID 9311822 . Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II" . Genes Dev . 11 (20): 2645–57. doi :10.1101/gad.11.20.2645 . PMC 316603 PMID 9334327 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor" . Genes Dev . 12 (19): 2992–6. doi :10.1101/gad.12.19.2992 . PMC 317190 PMID 9765201 . Ping YH, Rana TM (1999). "Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes" . J. Biol. Chem . 274 (11): 7399–404. doi :10.1074/jbc.274.11.7399 PMID 10066804 .
External links [ edit ]
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
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