Cannabaceae

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Fenclofenac
Names
Preferred IUPAC name
[2-(2,4-Dichlorophenoxy)phenyl]acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.047.373 Edit this at Wikidata
UNII
  • InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18)
    Key: IDKAXRLETRCXKS-UHFFFAOYSA-N
  • InChI=1/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18)
    Key: IDKAXRLETRCXKS-UHFFFAOYAG
  • OC(=O)Cc1ccccc1Oc2ccc(Cl)cc2Cl
Properties
C14H10Cl2O3
Molar mass 297.1 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) previously used in rheumatism. It has mild immunosuppressive effects[1] and may displace thyroid hormone from its binding protein.[2][3] It can also cause lichen planus.[4]

Due to its side effects it was withdrawn from the UK and US in the 1980s.

References

[edit]
  1. ^ Spiers EM, Watson NT, Beck JS, Chapman IV, Dettmar PW (November 1993). "The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation". Int. J. Immunopharmacol. 15 (8): 865–9. doi:10.1016/0192-0561(93)90003-h. PMID 7902830.
  2. ^ Allen PA, Taylor RT (December 1980). "Fenclofenac and thyroid function tests". Br Med J. 281 (6255): 1642. doi:10.1136/bmj.281.6255.1642. PMC 1715072. PMID 7448557.
  3. ^ Taylor R, Clark F, Griffiths ID, Weeke J (October 1980). "Prospective study of effect of fenclofenac on thyroid function tests". Br Med J. 281 (6245): 911–2. doi:10.1136/bmj.281.6245.911. PMC 1714224. PMID 7427506.
  4. ^ Ferguson MM, Wiesenfeld D, MacDonald DG (1984). "Oral mucosal lichenoid eruption due to fenclofenac". J Oral Med. 39 (1): 39–40. PMID 6232357.


source: https://en.wikipedia.org/wiki/Fenclofenac

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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