THC Science

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	89,619,149 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	99,529,841 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	1112
	71375
	ENSG00000053254
	ENSMUSG00000033713
	O00409
	Q499D0
	NM_005197; NM_001085471
	NM_183186
	NP_001078940; NP_005188
	NP_899009
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.^[5]^[6]

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000053254 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033713 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC 232156. PMID 9154802.
^ ^a ^b "Entrez Gene: CHES1 checkpoint suppressor 1".

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31". Genomics. 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID 8617492.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID 16102918.
Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer Res. 66 (17): 8397–403. doi:10.1158/0008-5472.CAN-06-0061. PMID 16951149.
Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets". Gastroenterology. 133 (5): 1475–86. doi:10.1053/j.gastro.2007.08.038. PMID 17983802.

External links[edit]

CHES1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000053254 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033713 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9154802-5] Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC 232156. PMID 9154802.

[entrez-6] "Entrez Gene: CHES1 checkpoint suppressor 1".

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