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FOXK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JXS, 2C6Y
Identifiers
Aliases	FOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
External IDs	OMIM: 147685; MGI: 1916087; HomoloGene: 18748; GeneCards: FOXK2; OMA:FOXK2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,644,662 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,309,896 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	3607
	68837
	ENSG00000141568
	ENSMUSG00000039275
	Q01167
	Q3UCQ1
	NM_004514; NM_181430; NM_181431
	NM_001080932; NM_001363033
	NP_004505
	NP_001074401; NP_001349962
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.^[5]^[6]

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141568 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039275 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR (Jul 1988). "Characterization of antigen receptor response elements within the interleukin-2 enhancer". Mol Cell Biol. 8 (4): 1715–24. doi:10.1128/MCB.8.4.1715. PMC 363332. PMID 3260003.
^ ^a ^b "Entrez Gene: FOXK2 forkhead box K2".

Further reading[edit]

Li C, Lusis AJ, Sparkes R, et al. (1992). "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF". Genomics. 13 (3): 665–71. doi:10.1016/0888-7543(92)90139-J. PMID 1339390.
Li C, Lai CF, Sigman DS, Gaynor RB (1991). "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7739–43. Bibcode:1991PNAS...88.7739L. doi:10.1073/pnas.88.17.7739. PMC 52378. PMID 1909027.
Nirula A, Moore DJ, Gaynor RB (1997). "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter". J. Biol. Chem. 272 (12): 7736–45. doi:10.1074/jbc.272.12.7736. PMID 9065434.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Liu PP, Chen YC, Li C, et al. (2003). "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)". Proteins. 49 (4): 543–53. doi:10.1002/prot.10227. PMID 12402362. S2CID 1142924.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tsai KL, Huang CY, Chang CH, et al. (2006). "Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins". J. Biol. Chem. 281 (25): 17400–9. doi:10.1074/jbc.M600478200. PMID 16624804.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

External links[edit]

FOXK2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q01167 (Forkhead box protein K2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141568 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039275 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3260003-5] Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR (Jul 1988). "Characterization of antigen receptor response elements within the interleukin-2 enhancer". Mol Cell Biol. 8 (4): 1715–24. doi:10.1128/MCB.8.4.1715. PMC 363332. PMID 3260003.

[entrez-6] "Entrez Gene: FOXK2 forkhead box K2".

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