FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[6]
FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.
· Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
· von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023
Hart AH, Willson TA, Wong M, Parker K, Robb L (August 2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochemical and Biophysical Research Communications. 333 (4): 1361–1369. doi:10.1016/j.bbrc.2005.06.044. PMID15982639.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction