Protein-coding gene in the species Homo sapiens
Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene .[5] [6]
EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer , particularly in patients with steroid receptor negative expression and HER‑2 overexpression[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000080224 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055540 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science . 298 (5600): 1912–34. Bibcode :2002Sci...298.1912M . doi :10.1126/science.1075762 . PMID 12471243 . S2CID 26554314 . ^ "Entrez Gene: EPHA6 EPH receptor A6" .^ Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer" . Oncology Letters . 15 (4): 5257–5263. doi :10.3892/ol.2018.7919 . PMC 5840743 PMID 29552165 .
Further reading [ edit ]
Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly . International Review of Cytology. Vol. 196. pp. 177–244. doi :10.1016/S0074-7696(00)96005-4 . ISBN 978-0-12-364600-2 . PMID 10730216 . Xu Q, Mellitzer G, Wilkinson DG (July 2000). "Roles of Eph receptors and ephrins in segmental patterning" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 355 (1399): 993–1002. doi :10.1098/rstb.2000.0635 . PMC 1692797 PMID 11128993 . Nakamoto T, Kain KH, Ginsberg MH (February 2004). "Neurobiology: New connections between integrins and axon guidance" . Current Biology . 14 (3): R121-3. Bibcode :2004CBio...14.R121N . doi :10.1016/j.cub.2004.01.020 PMID 14986683 . S2CID 2957639 . Yamaguchi Y, Pasquale EB (June 2004). "Eph receptors in the adult brain". Current Opinion in Neurobiology . 14 (3): 288–96. doi :10.1016/j.conb.2004.04.003 . PMID 15194108 . S2CID 26196696 . Murai KK, Pasquale EB (August 2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist . 10 (4): 304–14. doi :10.1177/1073858403262221 . PMID 15271258 . S2CID 23900846 . Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, et al. (July 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis" . Neuron . 17 (1): 9–19. doi :10.1016/S0896-6273(00)80276-7 PMID 8755474 . S2CID 1075856 . Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T (January 2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood . 95 (1): 221–30. doi :10.1182/blood.V95.1.221 . PMID 10607706 . Prevost N, Woulfe D, Tanaka T, Brass LF (July 2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred" . Proceedings of the National Academy of Sciences of the United States of America . 99 (14): 9219–24. Bibcode :2002PNAS...99.9219P . doi :10.1073/pnas.142053899 PMC 123121 PMID 12084815 . Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Research . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, et al. (March 2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers" . Clinical Chemistry . 50 (3): 490–9. doi :10.1373/clinchem.2003.026849 PMID 14726470 .
External links [ edit ] Overview of all the structural information available in the PDB for UniProt : Q62413 PDBe-KB .
Activity Regulation Classification Kinetics Types
Angiopoietin CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: Ersofermin FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )Palifermin Repifermin Selpercatinib Sprifermin Trafermin FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A TrkB
Agonists: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF BNN-20 Deoxygedunin Deprenyl Diosmetin DMAQ-B1 HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 R13 TDP6 TrkC
VEGF Others
Additional growth factors: Adrenomedullin Colony-stimulating factors (see here instead)Connective tissue growth factor (CTGF) Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF) Glia maturation factor (GMF) Hepatoma-derived growth factor (HDGF) Interleukins /T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF) Macrophage-stimulating protein (MSP; HLP, HGFLP) Midkine (NEGF2) Migration-stimulating factor (MSF; PRG4) Oncomodulin Pituitary adenylate cyclase-activating peptide (PACAP) Pleiotrophin Renalase Thrombopoietin (see here instead)Wnt signaling proteins Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction